The Biochemistry of Affective Disorders

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

p-Chlorophenylalanine: a specific depletor of brain serotonin.

1966 • 1,754 citations

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

1957 • 1,233 citations

Bodily Changes in Pain, Hunger, Fear and Rage

1929 • 1,164 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

1965 • 813 citations

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

1969 • 645 citations

A CONCEPT FOR A ROLE OF SEROTONIN AND NOREPINEPHRINE AS CHEMICAL MEDIATORS IN THE BRAIN

1957 • 637 citations

Antiamphetamine effects following inhibition of tyrosine hydroxylase.

1966 • 445 citations

5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides

1967 • 424 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

Effects of stress on the metabolism of norepinephrine, dopamine and serotonin in the central nervous system of the rat. I. Modifications of norepinephrine turnover.

1968 • 403 citations

Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone

1969 • 392 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

Cortisol Production in Depressive Illness

1970 • 371 citations

POTENTIATION OF THE ANTIDEPRESSIVE EFFECT OF A MONOAMINE-OXIDASE INHIBITOR BY TRYPTOPHAN

1963 • 340 citations

Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.

1966 • 326 citations

SELF-STIMULATION OF THE BRAIN AND THE CENTRAL STIMULANT ACTION OF AMPHETAMINE.

1964 • 313 citations

NORADRENALINE, 5-HYDROXYTRYPTAMINE, AND 5-HYDROXYINDOLEACETIC ACID IN HINDBRAINS OF SUICIDAL PATIENTS

1968 • 304 citations

Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

1968 • 294 citations

Resistance to Suppression by Dexamethasone of Plasma 11-O.H.C.S. Levels in Severe Depressive Illness

1968 • 278 citations

TRYPTOPHAN IN THE TREATMENT OF DEPRESSION

1967 • 274 citations

Plasma cortisol in depressive illness

1962 • 260 citations

5-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONING

1969 • 259 citations

Paradoxical Sleep — A Study of its Nature and Mechanisms

1965 • 258 citations

Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male Rats

1969 • 255 citations

5-Hydroxyindoleacetic Acid Levels in the Cerebrospinal Fluid of Depressive Patients treated with Probenecid

1970 • 253 citations

Amphetamine: Differentiation by d and l Isomers of Behavior Involving Brain Norepinephrine or Dopamine

1970 • 252 citations

The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid

1969 • 243 citations

Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

1968 • 242 citations

Catecholamine metabolism in affective disorders—III

1970 • 239 citations

Brain amines: Response to physiological stress

1963 • 231 citations

In vivo studies of the metabolism of norepinephrine in the central nervous system.

1968 • 228 citations

Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine.

1969 • 227 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan.

1958 • 209 citations

3-Methoxy-4-Hydroxy Phenylglycol (MHPG) Excretion in Depressive States

1968 • 208 citations

STRESS-INDUCED RELEASE OF BRAIN NOREPINEPHRINE AND ITS INHIBITION BY DRUGS.

1964 • 204 citations

ON THE INTRAVENOUS GLUCOSE TOLERANCE TEST

1957 • 200 citations

Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5HT) in the central nervous system of the rat (II) modifications of serotonin metabolism

1968 • 200 citations

The effect of immobilization stress on the activity of central monoamine neurons

1968 • 199 citations

The effect of imipramine of central 5-hydroxytryptamine neurons

1968 • 198 citations

5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patiens with manic-depressive psychosis

1969 • 189 citations

Tryptaminergic mechanisms in punished and nonpunished behavior.

1970 • 182 citations

Localization of the Adrenergic Feeding System in the Rat Diencephalon

1967 • 178 citations

Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine

1968 • 173 citations

Psychosis and Other Psychiatric Manifestations of Levodopa Therapy

1970 • 171 citations

Effect of Lithium on the Uptake of Noradrenaline by Synaptosomes

1967 • 171 citations

Stereotype hyperactive behaviour produced by dopamine in the absence of noradrenaline

1967 • 167 citations

Potentiation of a monoamine oxidase inhibitor by tryptophan

1969 • 167 citations

A sustained effect of electroconvulsive shock on the turnover of norepinephrine in the central nervous system of the rat.

1967 • 166 citations

The effects of 5-HTP on para-chlorophenylalanine (p-CPA) attenuation of “conflict” behavior

1970 • 163 citations

POTENTIATION OF MONOAMINE-OXIDASE INHIBITORS BY TRYPTOPHAN

1963 • 162 citations

Circadian rhythms in rat mid‐brain and caudate nucleus biogenic amine levels

1968 • 161 citations

Spinal Reflexes and Monoamine Liberation

1964 • 161 citations

Mineral metabolism in mania.

1966 • 161 citations

Effect of Oral Contraceptives on Depressive Mood Changes and on Endometrial Monoamine Oxidase and Phosphatases

1968 • 160 citations

Facilitation of Brain Self-Stimulation by Central Administration of Norepinephrine

1969 • 158 citations

Mineral Metabolism in Melancholia

1963 • 157 citations

EFFECTS OF L-DOPA IN PARKINSON'S DISEASE

1969 • 157 citations

Lithium ion: a specific psychopharmacological approach to the treatment of mania.

1960 • 157 citations

THE EXCRETION AND RETENTION OF INGESTED LITHIUM AND ITS EFFECT ON THE IONIC BALANCE OF MAN

1955 • 155 citations

3',5' CYCLIC ADENOSINE MONOPHOSPHATE IN DEPRESSION AND MANIA

1970 • 154 citations

Evoked Release of Norepinephrine and Serotonin from Brain Slices: Inhibition by Lithium

1968 • 150 citations

Tryptamine Metabolism in Depression

1965 • 150 citations

A CLINICAL AND BIOCHEMICAL STUDY OF A TRIAL OF IPRONIAZID IN THE TREATMENT OF DEPRESSION

1959 • 149 citations

PITUITARY-ADRENAL FUNCTION IN SEVERE DEPRESSIVE ILLNESS

1968 • 148 citations

"Hypersexuality" and Behavioral Changes in Cats Caused by Administration of p -Chlorophenylalanine

1970 • 146 citations

The effects of catecholamines on the central nervous system.

1959 • 145 citations

The effect of ethanol on the activity of central catecholamine neurones in rat brain

1966 • 144 citations

Decrease of 5-Hydroxytryptamine in the Brain provoked by Hydrocortisone and its Prevention by Allopurinol

1968 • 144 citations

Reaction of the Adrenal Cortex to Emotional Stress

1956 • 144 citations

Emotional and autonomic responses following hypothalamic chemical stimulation.

1964 • 143 citations

Catecholamine metabolism in affective disorders: I.

1965 • 135 citations

The effects of p-chlorophenylalanine on experimentally induced conflict in the rat

1969 • 135 citations

The effect of β-phenylethylamine on central and peripheral monoamine-containing neurons

1967 • 133 citations

The effects of noradrenaline on rat's behaviour

1970 • 133 citations

Tryptophan Pyrrolase—A Biochemical Factor in Depressive Illness?

1969 • 132 citations

New Theory of Cerebral Amine Function and its Clinical Application

1968 • 131 citations

Norepinephrine Metabolism and Drugs Used in the Affective Disorders: A Possible Mechanism of Action

1967 • 130 citations

MENTAL SYMPTOMS IN PARKINSONIAN PATIENTS TREATED WITH L-DOPA

1970 • 129 citations

Adrenal Cortical Activity in Pathological Emotional States : A Review

1966 • 126 citations

The effect of lithium on cerebral monoamine neurons

1967 • 125 citations

Norepinephrine Turnover and Metabolism in Rat Brain after Long-Term Administration of Imipramine

1970 • 125 citations

Hypothalamic β-Adrenergic “Satiety” System antagonizes an α-Adrenergic “Hunger” System in the Rat

1970 • 125 citations

Increased Turnover of Cerebral Norepinephrine during Rebound of Paradoxical Sleep in the Rat

1968 • 121 citations

Aminergic mechanisms in corpus striatum and amphetamine-induced stereotyped behaviour

1967 • 119 citations

The effect of prolonged lithium treatment on the synthesis rate and turnover of monoamines in brain regions of rats

1970 • 119 citations

The effects of lithium ion on H3 -norepinephrine metabolism in brain

1966 • 119 citations

Brain serotonin metabolism in isolated aggressive mice

1968 • 116 citations

Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain

1970 • 115 citations

Neuro-Psychopharmacology

1962 • 114 citations

EEG AND BEHAVIORAL CHANGES FOLLOWING MICROINJECTIONS OF ACETYLCHOLINE AND ADRENALINE IN THE BRAIN STEM OF CATS.

1963 • 111 citations

The effects of lithium salts on the turnover and metabolism of norepinephrine in rat brain

1969 • 111 citations

Brain amines and emotional stress

1966 • 109 citations

Longitudinal Studies of Sleep and Dream Patterns in Manic-Depressive Patients

1968 • 107 citations

The effects of tryptamine on the central nervous system, including a pharmacological procedure for the evaluation of iproniazidlike drugs.

1959 • 105 citations

Enhancement of Imipramine by Thyroid Stimulating Hormone: Clinical and Theoretical Implications

1970 • 105 citations

Insulin Tolerance Test in Depression

1969 • 105 citations

Daily Rhythm in the Noradrenaline Content of Rat Hypothalamus

1968 • 104 citations

Further Evaluation of Urinary 17-Hydroxycorticosteroids in Suicidal Patients

1969 • 104 citations

Effects of immobilization on rat liver tryptophan pyrrolase and brain 5‐hydroxytryptamine metabolism

1969 • 100 citations

Interrelationships Between the Endocrine System and Neuropsychiatry

1963 • 99 citations

Corticosteroids in Depressive Illness

1967 • 98 citations

Humoral Changes in Manic-Depressive Psychosis with Particular Reference to the Excretion of Catechol Amines in Urine

1958 • 98 citations

Behavioral Activation of Rats during Intraventricular Infusion of Norepinephrine

1970 • 97 citations

Neuronally activated metabolism of brain serotonin: Effect of lithium

1970 • 95 citations

SEQUENTIAL COMPARISON OF L-TRYPTOPHAN WITH E.C.T. IN SEVERE DEPRESSION

1970 • 94 citations

Modification by reserpine of the action of sympathomimetic amines in spinal cats; a classification of sympathomimetic amines.

1962 • 91 citations

The effect of prolonged lithium administration on cerebral monoamine neurons in the rat

1969 • 91 citations

Isolation, aggressiveness and brain 5-hydroxytryptamine turnover

1967 • 90 citations

Some Experiments in the Chemistry of Normal Sleep

1966 • 90 citations

Lithium Carbonate and Plasma Cortisol Response in the Affective Disorders

1968 • 89 citations

Diseases of the Nervous System

1959 • 89 citations

Decreased turnover in central 5-HT nerve terminals induced by antidepressant drugs of the imipramine type

1969 • 89 citations

Disclosure of Labile Monoamine Fractions in Brain and Their Correlation to Behaviour

1964 • 87 citations

Plasma Cortisol Levels in Depression

1966 • 87 citations

Brain Amines and Temperature Regulation

1968 • 87 citations

Differential Activation by Restraint Stress of a Mechanism to conserve Brain Catecholamines and Serotonin in Mice differing in Excitability

1968 • 87 citations

Toward a Biology of Depression: Some Suggestions from Neurophysiology

1969 • 85 citations

Central Aromatic Amine Levels and Behavior

1963 • 85 citations

ACTION OF SYMPATHOMIMETIC AND ALLIED AMINES ON THE CENTRAL NERVOUS SYSTEM OF THE CHICKEN

1965 • 84 citations

Corticosteroids in Depressive Illness

1967 • 84 citations

Effect of hydrocortisone on rat brain 5-hydroxytryptamine

1968 • 84 citations

PSYCHOTOMIMETIC DRUGS AND BRAIN BIOGENIC AMINES

1963 • 83 citations

Central Nervous System Serotonin and Norepinephrine Localization in Emotional and Non-Emotional Strains in Mice

1964 • 83 citations

Hydroxytryptamine turnover decreased by the antidepressant drug chlorimipramine

1970 • 82 citations

Changes in oral glucose tolerance during the menstrual cycle.

1968 • 82 citations

Intravenous Glucose Tolerance Test in Depression

1969 • 80 citations

Clinical experience with dihydroxyphenylalanine (DOPA) in depression

1963 • 79 citations

Brain Catecholamines: Relation to the Defense Reaction Evoked by Amygdaloid Stimulation in Cat

1965 • 79 citations

ADMINISTRATION OF A PERIPHERAL DECARBOXYLASE INHIBITOR WITH L-DOPA TO DEPRESSED PATIENTS

1970 • 78 citations

Inhibition by Hydrazine of Gluconeogenesis in the Rat

1970 • 78 citations

Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-dopa: correlation of behavioral and biochemical differences in two strains of mice.

1968 • 78 citations

Pituitary Adrenal Function and Depression

1967 • 76 citations

Neurochemical Differences between two Strains of Mice

1963 • 76 citations

Preoperative Emotional States and Adrenal Cortical Activity

1957 • 76 citations

ABNORMALITY OF THE BLOOD-CEREBROSPINAL FLUID BARRIER OF PATIENTS SUFFERING FROM A DEPRESSIVE ILLNESS

1960 • 74 citations

Effect of D-Amphetamine on Rat Brain Noradrenaline and Serotonin

1961 • 70 citations

Effect of environmental temperature on the turnover of noradrenaline in hypothalamus and other areas of rat brain

1969 • 70 citations

Study of a Patient With 48-Hour Manic-Depressive Cycles

1965 • 70 citations

THE ROLE OF ENDOGENOUS NOREPINEPHRINE IN THE TOXICITY OF D-AMPHETAMINE IN AGGREGATED MICE.

1964 • 70 citations

Longitudinal studies of the effect of monoamine oxidase inhibitors on sleep in man

1969 • 70 citations

Effects of Para-chlorophenylalanine on sleep in man

1969 • 70 citations

The effects of p-chlorophenylalanine, a depletor of brain serotonin, on behavior: II. Retardation of passive avoidance learning

1969 • 69 citations

Effect of alpha-methyltyrosine on operant behavior and brain catecholamine levels.

1969 • 69 citations

p-Chloroamphetamine temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine

1970 • 67 citations

CARBOHYDRATE METABOLISM IN BRAIN DISEASE

1954 • 67 citations

Excretion of 3-methoxy-4-hydroxymandelic acid (VMA) in depressed patients treated with antidepressant drugs

1964 • 66 citations

DIMINISHED MEMBRANE TRANSPORT IN MANIC-DEPRESSIVE PSYCHOSIS AND RECURRENT DEPRESSION

1968 • 66 citations

The effect of lithium chloride administration on brain and heart norepinephrine turnover rates

1969 • 65 citations

EFFECT OF L-DOPA ON DEPRESSION

1969 • 65 citations

Greater lowering of brain and adrenal catecholamines in group-housed than in individually-housed mice administered <scp>dl</scp>-x-methyltyrosine

1968 • 65 citations

FURTHER STUDIES ON: ONE DAY TREATMENT OF DEPRESSION WITH 5-HTP

1964 • 65 citations

Essential Role of Testosterone in the Sexual Stimulation induced by p-Chlorophenylalanine in Male Animals

1970 • 65 citations

An Evaluation of Depression as a Side Effect of Oral Contraceptives

1969 • 65 citations

Behavioral-Neurochemical Correlation in Reactive and Nonreactive Strains of Rats

1964 • 63 citations

Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain

1969 • 62 citations

Aggression in mice associated with changes in the monoamine-metabolism of the brain

1969 • 62 citations

Manic-Depressive Psychosis: An Alternative Conceptual Model

1968 • 62 citations

A PSYCHOENDOCRINE STUDY OF SEVERE PSYCHOTIC DEPRESSIVE CRISES

1965 • 61 citations

Effect of grouping on the level of brain norepinephrine in white swiss mice

1965 • 61 citations

Adrenal Cortical Activity Changes in Manic-Depressive Illness

1967 • 61 citations

The Diurnal Rhythm of Plasma Cortisol Concentration in Depression

1966 • 60 citations

Effects of Lithium Carbonate on Turnover and Metabolism of Norepinephrine in the Rat Brain – Correlation to Gross Behavioral Effects

1970 • 60 citations

POTENTIATION OF INSULIN HYPOGLYCÆMIA BY M.A.0.1. ANTIDEPRESSANT DRUGS

1966 • 60 citations

Catecholamine Metabolism in Affective Disorders

1969 • 60 citations

A SIGNIFICANT ELEVATION OF PLASMA MAGNESIUM LEVELS IN SCHIZOPHRENIA AND DEPRESSIVE STATES

1964 • 59 citations

Effects of amphetamine and desmethylimipramine on amines synthesis and release in central catecholamine-containing neurons

1969 • 59 citations

The effects of barbiturates on the activity of the catecholamine neurones in the rat brain

1966 • 59 citations

THE DISTRIBUTION OF ELECTROLYTES AND WATER IN PATIENTS AFTER TAKING LITHIUM CARBONATE

1967 • 58 citations

Urinary Adenosine 3', 5'-Monophosphate Excretion in Affective Disorders

1970 • 58 citations

The effects of p-chlorophenylalanine, a depletor of brain serotonin, on behavior: I. facilitation of discrimination learning

1967 • 57 citations

Modification of sympathetic function. Indirectly acting sympathomimetic amines.

1966 • 57 citations

RELIEF OF DEPRESSION WITHIN ONE DAY USING AN M.A.O. INHIBITOR AND INTRAVENOUS 5-HTP

1963 • 57 citations

Metabolic Balance Studies on the Effect of Lithium Salts in Manic-Depressive Psychosis

1968 • 57 citations

Total body sodium and potassium in depressive illness.

1960 • 57 citations

SOME OBSERVATIONS ON THE ESTIMATION OF TRYPTAMINE IN TISSUES

1966 • 56 citations

Reversal of α-methyltyrosine-induced behavioural depression with dihydroxyphenylalanine and amphetamine

1967 • 55 citations

Biochemical Changes in Psychotic Depression

1967 • 55 citations

THE EFFECTS OF LITHIUM ON ELECTROENCEPHALOGRAM, BEHAVIOR AND SERUM ELECTROLYTES

1970 • 54 citations

5-HYDROXYTRYPTOPHAN FOR DEPRESSION

1967 • 54 citations

Methysergide in Mania

1968 • 54 citations

Intellectual Changes Associated With Levodopa Therapy

1970 • 53 citations

Tryptophan Metabolism in Affective Psychoses

1966 • 53 citations

PITUITARY-ADRENAL FUNCTION IN DEPRESSION

1968 • 51 citations

Metatyrosine as a tool for selective protection of catecholamine stores against reserpine

1967 • 51 citations

Carbohydrate Metabolism in Mania

1970 • 50 citations

The Effect of Convulsive Therapy on Plasma Adrenaline and Noradrenaline

1955 • 50 citations

Serum and erythrocyte magnesium in patients with manic states during lithium treatment

1964 • 49 citations

A SIGNIFICANT ELEVATION OF PLASMA MAGNESIUM LEVELS IN SCHIZOPHRENIA AND DEPRESSIVE STATES

1964 • 48 citations

Studies on sodium transfer and 5-hydroxyindoles in depressive illness

1963 • 48 citations

WATER AND SODIUM IN TWO PSYCHOTICS

1959 • 46 citations

Blockade of L-dopa reversal of reserpine-induced conditioned avoidance response suppression by disulfiram.

1968 • 46 citations

Measurement of hyperactivity in rats in a dose-response-curve after intrahypothalamic norepinephrine injection

1969 • 45 citations

Potassium and Water Distribution in Depression

1966 • 45 citations

The effect of lithium and amphetamine on desmethylimipramine-Ro 4-1284 induced motor hyperactivity

1968 • 45 citations

Preferential utilization of newly synthesized norepinephrine in the brain stem of stressed rats

1970 • 45 citations

ADRENERGIC MECHANISMS

1961 • 45 citations

Corticosteroid Responses to Psychotherapy of Depressions

1967 • 44 citations

Effect of Emotion on Blood Corticotrophin and Cortisol Concentrations in Man

1962 • 43 citations

Imipramine and Lithium Effects on Biogenic Amine Transport in Depressed and Manic-Depressed Patients

1970 • 43 citations

HYPOTENSIVE COLLAPSE AND HYPOGLYCÆMIA AFTER MEBANAZINE — A MONOAMINE-OXIDASE INHIBITOR

1964 • 42 citations

Norepinephrine turnover and brain monoamine levels in aggressive mouse-killing rats

1969 • 42 citations

Lithium Ion Retention and Distribution

1968 • 42 citations

Adrenal Cortical Function in Anxious Human Subjects

1957 • 42 citations

Sodium Balance and Distribution in Lithium Carbonate Therapy

1970 • 41 citations

Biochemical and behavioural effects of tyrosine hydroxylase inhibition

1967 • 40 citations

Effect of electroshock on dopamine metabolism in rat brain

1968 • 40 citations

Diseases of the Nervous System.

1963 • 39 citations

The action of reserpine in imipramine-resistant depressive patients

1967 • 39 citations

Influence of adrenergic stimulant and blocking drugs on cerebral electrical activity in curarized animals.

1961 • 38 citations

Body weight and balance of water, sodium and potassium in depressed patients given electro-convulsive therapy.

1960 • 38 citations

Calcium Metabolism in States of Depression

1964 • 38 citations

Effect of dopalanine on behaviour in mice depleted of norepinephrine or serotonin

1969 • 38 citations

17-KETOSTEROID EXCRETION IN A CASE OF MANIC-DEPRESSIVE PSYCHOSIS

1954 • 37 citations

Central adrenergic synapses.

1966 • 37 citations

Thermoregulation: Effects of Environmental Temperature on Turnover of Hypothalamic Norepinephrine

1969 • 36 citations

Central Aromatic Amines and Behavior

1966 • 36 citations

Studies on the Metabolism of 5-Hydroxytryptamine (Serotonin) VI. Hydroxylation and Amines in Cold-Stressed Reserpinized Rats

1968 • 36 citations

Trial of Methysergide in Mania

1968 • 35 citations

Biochemical Aspects of Lithium in Affective Disorders

1968 • 35 citations

Effect of reserpine, alpha-methyl-p-tyrosine, p-chlorophenylalanine and pargyline on levorphanol-induced running activity in mice.

1969 • 35 citations

Amphetamine toxicity and brain monoamines in three models of stress

1969 • 35 citations

Retention and Distribution Patterns of Lithium, a Pharmacological Tool in Studying the Pathophysiology of Manic-Depressive Psychosis

1968 • 35 citations

Die Bedeutung der Monoaminoxydasehemmung als antidepressives Prinzip. I

1963 • 35 citations

Brain dopamine and the amphetamine-reserpine interaction

1967 • 34 citations

METHYSERGIDE IN MANIA

1969 • 34 citations

Variations in II-Hydroxycorticosteroids in Depression and Manic-Depressive Psychosis

1967 • 34 citations

Effect of changes of brain norepinephrine content on sleep cycle in rat

1968 • 34 citations

Correlation of Tryptamine-Induced Convulsions in Rats with Brain Tryptamine Concentration

1960 • 33 citations

Effects of various drugs on 3,4-dihydroxyphenylalanine (dl-DOPA)-induced excitation (agressive behavior) in mice

1970 • 33 citations

Clinical and Biochemical Analysis of a Case of Manic-Depressive Psychosis Showing Regular Weekly Cycles

1945 • 33 citations

Depression, glucose tolerance, peripheral glucose uptake and their alterations under the influence of anti-depressive drugs of the hydrazine type

1965 • 33 citations

Effect of 1,4-butanediol and other butyric acid congeners on brain catecholamines

1968 • 32 citations

Die Bedeutung der Monoaminoxydasehemmung als antidepressives Prinzip. II

1963 • 32 citations

L-DOPA IN DEPRESSED PATIENTS

1970 • 31 citations

Neurochemical effects of imipramine and amphetamine in aggressive mouse-killing (muricidal) rats

1970 • 31 citations

Die Wirkung von Dopa auf gehemmte Depressionen

1966 • 29 citations

Concurrent changes in hypothalamic and cardiac catecholamine levels after anesthetics, tranquilizers and stress in a subhuman primate.

1966 • 29 citations

CYCLIC A.M.P. IN DEPRESSION AND MANIA

1970 • 28 citations

Tissue Levels of Norepinephrine and Epinephrine in Hemorrhagic Shock

1963 • 28 citations

Lithium Retention and Excretion

1969 • 28 citations

Brain Electrolytes in Depressive and Alcoholic Suicides

1969 • 27 citations

National Institute of Mental Health

1998 • 27 citations

Body Water Variations in Manic-Depressive Psychosis

1967 • 27 citations

The Relationship Between Glucose Tolerance, Body Weight, and Clinical State in Melancholia

1958 • 26 citations

Behavioural and electrophysiological effects of catecholamines.

1966 • 26 citations

ORAL CONTRACEPTIVES AND DEPRESSION

1969 • 26 citations

Influencing the human indoleamine metabolism by means of a chlorinated amphetamine derivative with antidepressive action (p-Chloro-N-Methylamphetamine)

1968 • 26 citations

Mood, Motility and 17-Hydroxycorticoid Excretion; A Polyvariable Case Study

1966 • 26 citations

Melancholia, Glucose Tolerance and Body Weight

1958 • 25 citations

The influence of centrally active amine induced blood pressure changes on the electroencephalogram and behavior

1967 • 25 citations

The Relationship Between 17-Hydroxycorticosteroid Excretion and Glucose Utilization in Depressions

1964 • 25 citations

Modification de l'activité électrique cérébrale du lapin sous l'effet de micro-injections de précurseurs des monoamines dans les structures somnogènes bulbaires et pontiques

1966 • 24 citations

Increased rate of catecholamine synthesis during respiratory acidosis

1968 • 24 citations

L-TRYPTOPHAN IN DEPRESSION

1970 • 24 citations

Tryptophan Pyrrolase Induced in Human Liver by Hydrocortisone: Effect on Excretion of Kynurenine

1966 • 24 citations

EFFECT OF ELECTROCONVULSIVE THERAPY ON WATER METABOLISM IN PSYCHOTIC PATIENTS

1949 • 23 citations

17-Hydroxycorticosteroid and Vanillylmandelic Acid Excretion in a Rapidly Cycling Manic-Depressive

1968 • 23 citations

Effect of oxygen on brain serotonin metabolism in rats

1968 • 23 citations

Metabolic Variations in Manic-Depressive Psychosis

1956 • 23 citations

DEPRESSION DURING L-DOPA TREATMENT

1969 • 23 citations

A CLINICAL TRIAL OF PARGYLINE AND DOPA IN PSYCHOTIC SUBJECTS.

1964 • 23 citations

NEUROHORMONE LEVELS IN BRAIN AFTER CNS STIMULATION INCLUDING ELECTROTHERAPY.

1964 • 23 citations

Variations in Body Water during Recovery from Depression

1967 • 21 citations

Effect of Dl-p-chloro-N-methylamphetamine on the concentrations of monoamines in the cat and rat brain and rat heart

1965 • 21 citations

Plasma Hydrocortisone in Mental Diseases

1964 • 21 citations

The variability of plasma 17-hydroxycorticosteroids—levels in affective illness and schizophrenia

1965 • 20 citations

The Clinical Manifestations of Depressive Illness with Abnormal Acetyl Methyl Carbinol Metabolism

1962 • 20 citations

Pharmacology of the Mechanism of Certain Effects of Reserpine in the Rat

1967 • 20 citations

Changes in Catechol Amine Response to Successive Electric Convulsive Treatments

1959 • 20 citations

Verbally Retarded Depression and Sodium Metabolism

1963 • 20 citations

Effects of electroconvulsive shock and prior stress on brain amine levels

1968 • 19 citations

SERIAL BIOCHEMICAL, CLINICAL AND ELECTROENCEPHALOGRAPHIC STUDIES IN AFFECTIVE ILLNESS.

1964 • 19 citations

Norepinephrine Levels in Various Areas of Rat Brain during Cold Acclimation

1968 • 19 citations

L-TRYPTOPHAN VERSUS E.C.T.

1970 • 18 citations

Importance of noradrenaline synthesis for the interaction between desipramine and reserpine

1966 • 18 citations

Presynaptic effects of lithium on cholinergic synaptic transmission in aplysia neurons

1968 • 18 citations

Adenosine 3′:5′-cyclic monophosphate phosphodieterase: kinetic and inhibitor studies

1970 • 18 citations

Sodium-22 retention and 17-hydroxycorticosteroid excretion in affective disorders: A preliminary report

1969 • 17 citations

Different mechanisms of drug-induced release of noradrenaline and its congeners α-methylnoradrenaline and metaraminol

1968 • 17 citations

Treatment of Mania with Cinanserin, an Antiserotonin Agent

1970 • 17 citations

Effect of chronic administration of cortisone on the tryptophan induced changes in amine levels in the rat brain.

1968 • 17 citations

Glucose Tolerance in Depression

1968 • 16 citations

Brain Norepinephrine and Behavior

1965 • 16 citations

[Orientative clinical trials on the effects of dihydroxyphenylalanine (1-dopa) in endogenous depression].

1965 • 16 citations

Central effects of 3,4-dihydroxyphenylalanine and 5-hydroxy tryptophane on tetrabenazine pretreated rabbits with special reference to the possible role of catecholamine and serotonin in the brain

1968 • 16 citations

Electrophysiological studies on the functional relationship between the nonspecific thalamic nuclei and the cerebellum in dogs

1963 • 15 citations

Development of tolerance to the behavioural depressant effects of α-methyltyrosine

1968 • 15 citations

Activators and Inhibitors of Hexokinase in Human Blood

1951 • 15 citations

Chemical Pathology of the Nervous System

1962 • 15 citations

L-tryptophan in depression.

1970 • 14 citations

Sedative-like Effect of Epinephrine

1965 • 14 citations

EFFECTS OF INTRAVENTRIGULARLY ADMINISTERED ADRENALINE ON RABBIT’S EEG AND THEIR MODIFICATIONS BY ADRENERGIC BLOCKING AGENTS

1968 • 14 citations

Possible Role of Hydrazine Group in Hypoglycemia Associated with the Use of Certain Monoamine-oxidase Inhibitors (MAOI's)

1969 • 13 citations

A clinical trial of methysergide and lithium in mania

1969 • 13 citations

Multiple biochemical correlates of manic-depressive illness

1968 • 12 citations

NORADRENALINE CONTENT OF CEREBROSPINAL FLUID IN MENTAL DISEASES

1966 • 12 citations

L-TRYPTOPHAN IN DEPRESSION

1970 • 12 citations

Methysergide as a Treatment for Mania

1970 • 11 citations

Some aspects of the metabolism of glucose and of the non-esterified fatty acids in depressive patients

1966 • 11 citations

Sodium Transfer From Plasma to CSF in Severe Depressive Illness

1969 • 11 citations

Clinical and Biochemical Investigations in a Manic-Depressive with Short Cycles

1950 • 11 citations

Circadian Rhythm of Adrenal Cortical Activity in Depression

1968 • 10 citations

Psychic Effects in Patients Treated With Levodopa

1970 • 10 citations

Interaction between cerebral amines and 4-hydroxybutyrate in the induction of sleep

1969 • 10 citations

[Urinary excretion of 5-hydroxyindolacetic acid (5-HIAA) in 150 patients with depressive syndrome and maniacal agitation. (Its modifications by 5-hydroxy-tryptophan loading and therapy in the depressive states)].

1963 • 9 citations

Electroencephalographic studies on the action of monoamine oxidase inhibitor

1964 • 9 citations

Effect of hyperbaric oxygen on monoamine metabolism in central and peripheral tissues of the rat

1968 • 9 citations

CEREBRAL AMINES AND BEHAVIOUR

1968 • 8 citations

Behavioural effects of α-methyltyrosine administered in the diets of mice pretreated with a monoamine oxidase inhibitor

1968 • 8 citations

Morning and afternoon plasma 17-hydroxycorticosteroid levels during affective psychosis.

1967 • 8 citations

Catechol amines excretion in manic depressive poychosis.

1961 • 7 citations

EFFECTS OF CHLORPROMAZINE, AZACYCLONOL AND CHLORDIAZEPOXIDE ON BRAIN CATECHOLAMINE CONTENTS OF STRESSED RATS

1963 • 7 citations

Wirkung von 5-Hydroxytryptophan auf zentrale adrenerge Erregungen

1965 • 6 citations

Urinary 17-Ketosteroid Fractionation in Depression: a Preliminary Report

1969 • 6 citations

Personality and Body Composition in Monozygotic Twins with an Affective Disorder

1969 • 6 citations

Clinical pharmacology and pending biochemical questions of lithium therapy.

1968 • 6 citations

Adrenocortical function in depressive states--study of circadian variation in plasma and urinary steroids.

1968 • 6 citations

[Contribution to norepinephrine and serotonin metabolism in the rat brain following stress conditions].

1966 • 5 citations

METHYSERGIDE IN MANIA

1969 • 5 citations

Tissue Catecholamine Levels in Prolonged Oligemic Hypotension.

1965 • 5 citations

The effect of some monoamine oxidase inhibitors on gluconeogenesis

1969 • 4 citations

DIENCEPHALON: AUTONOMIE AND EXTRAPYRAMIDAL FUNCTIONS

1954 • 4 citations

Examination of Immigrant Doctors

1970 • 3 citations

BLOOD ACETALDEHYDE LEVELS IN AFFECTIVE DISORDERS.

1964 • 2 citations

Norepinephrine and 5-Hydroxytryptamine in the CNS of Rats under Continuous Illumination and Total Darkness

1967 • 2 citations

L-TRYPTOPHAN IN DEPRESSION

1970 • 2 citations

The effect of normal and schizophrenic serum on the catecholamine levels in rabbit hypothalamus

1968 • 1 citations

Selective blockade by mephentermine of reserpine-induced serotonin depletion

1968 • 1 citations

Marsilid and epinephrine metabolism.

1959 • 1 citations

Deleted Work

1955 • 0 citations