Squalene Epoxidase — Enzymology and Inhibition

Distribution of Hopanoid Triterpenes in Prokaryotes

1984 • 711 citations

Anaerobic nutrition of Saccharomyces cerevisiae. I. Ergosterol requirement for growth in a defined medium

1953 • 551 citations

Recent Trends in the Discovery, Development, and Evaluation of Antifungal Agents

1987 • 477 citations

Allylamine Derivatives: New Class of Synthetic Antifungal Agents Inhibiting Fungal Squalene Epoxidase

1984 • 422 citations

Steroids and Squalene in Methylococcus capsulatus grown on Methane

1971 • 284 citations

Antifungal activity of the allylamine derivative terbinafine in vitro

1987 • 240 citations

Allylamine Derivatives—a New Class of Active Substances in Antifungal Chemotherapy

1987 • 226 citations

2,3-Oxidosqualene, an Intermediate in the Biological Synthesis of Sterols from Squalene¹

1966 • 219 citations

Recent Advances in Chemotherapy

1939 • 215 citations

In vitro and in vivo evaluation of antifungal agents

1989 • 181 citations

Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes

1985 • 177 citations

Enzymic Conversion of Squalene 2,3-Oxide to Lanosterol and Cholesterol

1966 • 176 citations

Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent

1985 • 167 citations

Studies on Squalene Epoxidase of Rat Liver

1970 • 163 citations

Solubilization and partial characterization of rat liver squalene epoxidase.

1975 • 158 citations

ON THE CONVERSION OF SQUALENE TO LANOSTEROL IN VITRO

1957 • 136 citations

Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate

1986 • 128 citations

Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

1986 • 125 citations

Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity

1984 • 122 citations

The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase

1976 • 119 citations

Squalene Epoxidase of Rat Liver

1972 • 112 citations

Recent Advances in Chemotherapy

1990 • 111 citations

In vitro activity of naftifine, a new antifungal agent

1981 • 106 citations

Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae

1983 • 100 citations

SYNTHESIS OF LIPIDS IN RESTING CELLS OF SACCHAROMYCES CEREVISIAE

1955 • 100 citations

In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3- dihydrosqualene and derivatives, and by other ammonium-containing molecules

1985 • 95 citations

Purification and properties of a soluble protein activator of rat liver squalene epoxidase.

1977 • 91 citations

Purification and properties of sterol carrier protein1.

1976 • 87 citations

The interaction of representative members from two classes of antimycotics—the azoles and the allylamines—with cytochromes P-450 in steroidogenic tissues and liver

1985 • 87 citations

Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans

1984 • 86 citations

Speculations on the Evolution of Sterol Structure and Functio

1979 • 82 citations

Non‐specific Lanosterol and Hopanoid Biosynthesis by a Cell‐Free System from the Bacterium Methylococcus capsulatus

1980 • 75 citations

Porphyrin mutants of : Correlated lesions in sterol and fatty acid biosynthesis

1974 • 73 citations

Squalene and ergosterol biosynthesis in fungi treated with naftifine, a new antimycotic agent

1982 • 70 citations

The mode of antifungal action of tolnaftate

1986 • 70 citations

24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase.

1986 • 68 citations

Supernatant protein factor facilitates intermembrane transfer of squalene.

1980 • 63 citations

Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system

1977 • 59 citations

Biosynthesis of Terpenoids

1979 • 56 citations

Purification and partial characterization of squalene epoxidase from rat liver microsomes

1982 • 54 citations

Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids.

1980 • 53 citations

Inhibitory Effect of Antifungal Agents on Germ Tube Formation in Candida albicans. Hemmeffekt antifungaler Wirkstoffe auf die Keimschlauchbildung von Candida albicans

1987 • 50 citations

Effect of Allylamine Antimycotic Agents on Fungal Sterol Biosynthesis Measured by Sterol Side-chain Methylation

1985 • 48 citations

Squalene epoxidase as the target of antifungal allylamines

1987 • 44 citations

Properties of a particulate squalene epoxidase from Candida albicans

1984 • 42 citations

Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives

1988 • 40 citations

Effects of Antifungal Agents on Ergosterol Biosynthesis in Candida albicans and Trichophyton mentagrophytes: Differential Inhibitory Sites of Naphthiomate and Miconazole

1985 • 39 citations

Yeast mutant requiring only a sterol as growth supplement

1974 • 37 citations

Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi

1978 • 31 citations

Inhibition of fungal and mammalian sterol biosynthesis by 2‐aza‐2,3‐dihydrosqualene

1986 • 29 citations

Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues

1977 • 27 citations

Effect of the allyiamine antifungal drug SF 86–327 on the growth and sterol synthesis of promastigotes

1985 • 27 citations

Enzymic epoxidation of squalene variants

1975 • 25 citations

Role of supernatant protein factor and anionic phospholipid in squalene uptake and conversion by microsomes.

1984 • 25 citations

In vitro assay of squalene epoxidase of Saccharomyces cerevisiae

1987 • 25 citations

Effects of unsaturated fatty acid deprivation on neutral lipid synthesis in Saccharomyces cerevisiae

1982 • 23 citations

Considerations on the evolution of steroids as membrane components

1982 • 22 citations

Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi

1978 • 18 citations

A possible regulatory role of squalene epoxidase in chinese hamster ovary cells

1984 • 10 citations

Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds

1982 • 10 citations

Effect of detergents on sterol synthesis in a cell-free system of yeast

1982 • 9 citations

Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems

1969 • 9 citations

Regulation of rat liver microsomal squalene epoxidase: Inactivation of the supernatant protein factor by nucleotides

1985 • 8 citations

Subcellular Sites Involved in Lipid Synthesis in Saccharomyces cerevisiae

1967 • 7 citations

ChemInform Abstract: ENZYMIC EPOXIDATION OF SQUALENE VARIANTS

1975 • 6 citations

Deleted Work

1955 • 0 citations