Concentrations of Metabolites and Binding Sites. Implications in Metabolic Regulation

Physical chemistry of macromolecules

2007 • 3,839 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

Molecular Biology of the Gene

1970 • 2,116 citations

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin

1967 • 1,139 citations

Respiratory Enzymes in Oxidative Phosphorylation

1958 • 900 citations

Adenosine Triphosphate Conservation in Metabolic Regulation

1967 • 878 citations

Eine einfache Technik der extrem schnellen Abk�hlung gr��erer Gewebest�cke

1960 • 866 citations

Physical Chemistry of Macromolecules

1962 • 851 citations

Wege des Wasserstoffs in der lebendigen Organisation

1958 • 635 citations

The Catalytic and Regulatory Properties of Enzymes

1968 • 603 citations

SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE

1954 • 595 citations

Allosteric Inhibition of Rat Liver Fructose 1,6-Diphosphatase by Adenosine 5'-Monophosphate

1965 • 521 citations

Ionic Mobility in Muscle Cells

1969 • 510 citations

Crystallization, Characterization and Metabolic Regulation of Two Types of Pyruvate Kinase Isolated from Rat Tissues*

1967 • 456 citations

Carbohydrate Metabolism and Its Disorders.

1969 • 415 citations

Molecular Biology of the Gene

1966 • 396 citations

Fluorescence Spectra and Polarization of Glyceraldehyde-3-phosphate and Lactic Dehydrogenase Coenzyme Complexes

1958 • 373 citations

The kinetic properties of citrate synthase from rat liver mitochondria

1969 • 346 citations

MEASUREMENT OF ACTIVITY OF SINGLE MOLECULES OF β-D-GALACTOSIDASE

1961 • 339 citations

Kinetic Evidence for Multiple Binding Sites on Phosphofructokinase

1966 • 336 citations

Role of Adenosine 3′,5′-Monophosphate in the Effects of Insulin and Anti-insulin Serum on Liver Metabolism

1968 • 328 citations

The Effect of Palmityl Coenzyme A on Glucose 6-Phosphate Dehydrogenase and Other Enzymes

1966 • 272 citations

Binding of bilirubin to human serum albumin — determination of the dissociation constants

1969 • 253 citations

Biological Feedback Control at the Molecular Level

1965 • 250 citations

Glycerol Metabolism in Yeasts

1968 • 249 citations

ZONE BEHAVIOR OF ENZYMES

1943 • 235 citations

Control of Glycogen Metabolism

1965 • 230 citations

Control of Gluconeogenesis in Liver

1969 • 219 citations

Regulation of Glycogenolysis in Muscle

1964 • 219 citations

Enzyme Concentrations in Tissues

1967 • 215 citations

Cooperation of glycolytic enzymes

1969 • 214 citations

The Role of Cyclic AMP in the Control of Carbohydrate Metabolism

1969 • 210 citations

Spontaneous and Enzymatically Catalyzed Anomerization of Glucose 6-Phosphate and Anomeric Specificity of Related Enzymes

1965 • 201 citations

Regulation of glutamine synthetase. 8. ATP: glutamine synthetase adenylyltransferase, an enzyme that catalyzes alterations in the regulatory properties of glutamine synthetase.

1967 • 199 citations

Macromolecular Organization of Enzyme Systems

1966 • 185 citations

Regulation of Liver Pyruvate Kinase and the Phosphoenolpyruvate Crossroads

1970 • 183 citations

Pyruvate Carboxylase

1966 • 169 citations

Equilibrium relations between pyridine nucleotides and adenine nucleotides and their roles in the regulation of metabolic processes

1969 • 167 citations

STUDIES ON A LIPOIC ACID-ACTIVATING SYSTEM

1958 • 166 citations

1-Acylglycerol 3-Phosphate Acyltransferase from Rat Liver

1969 • 162 citations

Effects of ischaemia on metabolite concentrations in rat liver

1970 • 158 citations

A New Model for the Living Cell: A Summary of the Theory and Recent Experimental Evidence in Its Support

1969 • 154 citations

The active chemical state of <scp>d</scp>-glyceraldehyde 3-phosphate in its reactions with <scp>d</scp>-glyceraldehyde 3-phosphate dehydrogenase, aldolase and triose phosphate isomerase

1969 • 148 citations

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

1965 • 137 citations

Disequilibrium in the triose phosphate isomerase system in rat liver

1969 • 134 citations

Genetics and Metabolism

1964 • 128 citations

Enzymes Involved in Fructose Metabolism in Liver and the Glyceraldehyde Metabolic Crossroads

1969 • 127 citations

INHIBITION OF SUCCINIC DEHYDROGENASE BY OXALACETATE

1948 • 117 citations

Adenyl cyclase and hormone action III. Calcium requirement for ACTH stimulation of adenyl cyclase

1969 • 115 citations

Citrate inhibition of phosphofructokinase and the Pasteur effect

1965 • 115 citations

The Effect of Palmityl Coenzyme A on Pigeon Liver Fatty Acid Synthetase

1968 • 114 citations

The Enzymatic Synthesis of Holotranscarboxylase from Apotranscarboxylase and (+)-Biotin

1964 • 111 citations

BIOCHEMICAL LESIONS AND LETHAL SYNTHESIS

1964 • 104 citations

Magnesium, Potassium, and the Adenylate Kinase Equilibrium

1970 • 102 citations

ATP‐dependent inactivation of heart muscle pyruvate dehydrogenase and reactivation by Mg⁺⁺

1969 • 93 citations

Protein Subunits: A Table (Second Edition)

1969 • 92 citations

The Significance of the Structural and Functional Similarities of Bacteria and Mitochondria

1969 • 91 citations

Interrelations between fatty acid oxidation and the control of gluconeogenesis in perfused rat liver

1968 • 90 citations

Magnesium binding by Escherichia coli ribosomes

1966 • 89 citations

Calculation of free magnesium, calcium and potassium in muscle

1961 • 87 citations

Metabolic Regulation and Enzyme Action

1970 • 83 citations

Diffusion of ATP in sperm flagella

1970 • 80 citations

Mechanism for the Stimulation in vivo of Hepatic Gluconeogenesis by Glucagon

1966 • 73 citations

Regulation of the Level of Key Enzymes of Glycolysis and Gluconeogenesis in Liver

1969 • 71 citations

The intracellular distribution of pyridine nucleotides in rat liver

1956 • 69 citations

ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS

1969 • 67 citations

The Quaternary Structure of Proteins

1966 • 62 citations

Energy Production in Rat Parotid Gland

1970 • 62 citations

Control of gluconeogenesis by acetyl CoA in rats treated with glucagon and anti-insulin serum

1966 • 53 citations

Muscle fructose-1, 6-diphosphatase

1964 • 51 citations

Insulin-stimulated glycogen formation in rat diaphragm. Levels of tissue intermediates in short-time experiments

1960 • 49 citations

Distribution of hexokinase and glucokinase between parenchymal and non‐parenchymal cells of rat liver

1969 • 46 citations

Equilibria of two-partner reactions of energy supplying metabolism in muscle

1962 • 45 citations

Enzymic assay of pyridoxal phosphate using tyrosine apodecarboxylase and tyrosine-1-14C

1968 • 44 citations

The effects of Ca²⁺ and ADP on the activity of NAD‐linked isocitrate dehydrogenase of muscle

1969 • 42 citations

Interaction of Human Hemoglobin with Adenine Nucleotides

1969 • 40 citations

Oxalacetate Keto-Enol Tautomerase

1969 • 39 citations

Effects of Adenosine Triphosphate and Magnesium Ions on the Fumarase Reaction

1969 • 39 citations

Computer Simulation Studies of Mammalian Pyruvate Kinase

1967 • 38 citations

Adenine nucleotides and the adenylate kinase equilibrium in livers of foetal and newborn rats

1970 • 38 citations

Subunits of rat liver mitochondrial malate dehydrogenase

1969 • 32 citations

Cytoplasmic Control over the Nuclear Events of Cell Reproduction

1969 • 31 citations

The inhibition of pyruvate kinase by ATP: A Mg++ buffer system for use in enzyme studies

1969 • 31 citations

Hybridization Experiments: Evidence of Dissociation Equilibrium in Hemerythrin

1965 • 31 citations

The lac repressor-operator interaction IV. Assay and purification of operator DNA

1970 • 30 citations

Acetyl CoA level in perfused rat lyver during gluconeogenesis and ketogenesis

1968 • 28 citations

Glycogen-bound enzymes: A new method of isolation

1969 • 24 citations

DIGITAL COMPUTER SIMULATION OF SYSTEMS APPARENTLY COMPARTMENTED AT THE CELLULAR LEVEL*

1963 • 24 citations

Konzentrationsänderungen von Effektoren gluconeogenetischer Schlüsselenzyme in der Rattenleber unter gluconeogenetischen Bedingungen

1967 • 24 citations

Activation of pyruvate kinase of Mucor Rouxii by manganese ions

1970 • 20 citations

Compartmentation of the Metabolism of Lactose, Galactose and Glucose in Escherichia coli

1968 • 16 citations

Preservation of washed bovine spermatozoa in a synthetic medium at room temperature

1959 • 15 citations

Competition of several enzymes for a common substrate: a possible model of cellular events

1969 • 11 citations

Significance of the Michaelis Constant

1963 • 9 citations

Microfluorometric study of responses of the cytosol to mitochondrial substrates

1967 • 9 citations

Carbohydrate Metabolism

1961 • 9 citations

THE pH OF INTRACELLULAR WATER*

1966 • 7 citations