Enzyme pattern directed chemotheraphy

Eine einfache Technik der extrem schnellen Abk�hlung gr��erer Gewebest�cke

1960 • 866 citations

Enzymology of Cancer Cells

1977 • 641 citations

Enzymology of Cancer Cells

1977 • 420 citations

Selective Uridine Triphosphate Deficiency Induced by d-Galactosamine in Liver and Reversed by Pyrimidine Nucleotide Precursors

1974 • 240 citations

Mammalian Galactokinase

1965 • 136 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

A New Assay of Thymidylate Synthetase Activity Based on the Release of Tritium from Deoxyuridylate-5-3H

1967 • 122 citations

BIOCHEMISTRY AND BIOLOGICAL EFFECTS OF THE PYRAZOFURINS^* (PYRAZOMYCINS): INITIAL CLINICAL TRIAL

1975 • 106 citations

Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine.

1974 • 105 citations

Control of gene expression in carbohydrate, pyrimidine and DNA metabolism

1971 • 93 citations

Developmental Aspects and Some Characteristics of Mammalian Galactose 1-Phosphate Uridyltransferase

1966 • 89 citations

Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines

1974 • 84 citations

Metabolism of hepatomas of different growth rates in situ and during ischemia.

1971 • 80 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

THE MECHANISM OF ACTION OF 3‐DEAZAURIDINE IN TUMOR CELLS SENSITIVE AND RESISTANT TO ARABINOSYLCYTOSINE^*

1975 • 74 citations

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

1973 • 74 citations

Experimental Antitumor Activity of Pyrazomycin

1973 • 72 citations

Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver.

1971 • 70 citations

The regulation of pyrimidine nucleotide level and its role in experimental Hepatitis

1973 • 64 citations

5,10-Methylenetetrahydrofolic Dehydrogenase from Bakers' Yeast

1962 • 57 citations

Ordered and specific pattern of gene expression in neoplasia

1973 • 38 citations

Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism

1977 • 38 citations

Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping.

1977 • 36 citations

Irreversible inhibition of dehalogenation of 5-iodouracil by 5-diazouracil and reversible inhibition by 5-cyanouracil.

1970 • 33 citations

Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.

1974 • 22 citations

Biochemical strategy of the cancer cell: Malignant transformationlinked enzymatic imbalance

1975 • 13 citations

Aspects of the biochemical pharmacology of cytembena.

1975 • 11 citations