Catecholamines and Affective Illness: Studies with L-DOPA and Alpha-Methyl-Para-Tyrosine

Arzneimittelforschung

2005 • 8,820 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.

1962 • 2,236 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Psychological Statistics.

1963 • 966 citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

1965 • 813 citations

Manic Depressive Illness.

1970 • 720 citations

Treatment of Parkinsonism With Levodopa

1969 • 602 citations

THE IDENTIFICATION OF 5-HYDROXY-3-INDOLEACETIC ACID IN NORMAL URINE AND A METHOD FOR ITS ASSAY

1955 • 552 citations

B. TYROSINE HYDROXYLASE

1966 • 493 citations

Methods for Reliable Longitudinal Observation of Behavior

1963 • 480 citations

Zur Ätiologie und Nosologie endogener depressiver psychosen

1966 • 383 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

L-Dopa: Effect on Concentrations of Dopamine, Norepinephrine, and Serotonin in Brains of Mice

1970 • 332 citations

L-Dopa-Induced Release of Cerebral Monoamines

1970 • 327 citations

Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.

1967 • 308 citations

The localization of monoaminergic blood-brain barrier mechanisms.

1966 • 299 citations

END--OR BEGINNING?

1965 • 277 citations

Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients

1971 • 257 citations

5-Hydroxyindoleacetic Acid Levels in the Cerebrospinal Fluid of Depressive Patients treated with Probenecid

1970 • 253 citations

Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

1968 • 242 citations

Catecholamine metabolism in affective disorders—III

1970 • 239 citations

A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Introduction.

1966 • 219 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

3-Methoxy-4-Hydroxy Phenylglycol (MHPG) Excretion in Depressive States

1968 • 208 citations

Concentrations of 5-hydroxyindolylacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid

1966 • 189 citations

5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patiens with manic-depressive psychosis

1969 • 189 citations

Treatment of Parkinson's Syndrome with L Dihydroxyphenylalanine (Levodopa)

1970 • 184 citations

L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.

1970 • 181 citations

Behavioral and biochemical effects ofl-DOPA after peripheral decarboxylase inhibition

1969 • 171 citations

THE METABOLISM OF [C¹⁴]NORADRENALINE BY CAT BRAIN IN VIVO*

1963 • 166 citations

Biochemical and pharmacologic effects of α-methyltyrosine in man

1968 • 166 citations

5-Hydroxyindoles in Human Cerebrospinal Fluids

1960 • 162 citations

Manic-Depressive Illness

1970 • 158 citations

EFFECTS OF L-DOPA IN PARKINSON'S DISEASE

1969 • 157 citations

Measurement of acid monoamine metabolites in human and animal cerebrospinal fluid

1968 • 150 citations

A CLINICAL AND BIOCHEMICAL STUDY OF A TRIAL OF IPRONIAZID IN THE TREATMENT OF DEPRESSION

1959 • 149 citations

L-DOPA IN POSTENCEPHALITIC PARKINSONISM

1969 • 144 citations

Studies of Alpha-methyl-para-tyrosine, L-dopa, and L-tryptophan in Depression and Mania

1971 • 137 citations

INHIBITION OF CATECHOLAMINE SYNTHESIS IN MAN WITH ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE

1965 • 126 citations

Die Temperamente in den Familien der monopolaren und bipolaren phasischen Psychosen

1962 • 122 citations

DRUG‐INDUCED CHANGES IN THE CONCENTRATION OF 5‐OR INDOLYL COMPOUNDS IN CEREBROSPINAL FLUID AND CAUDATE NUCLEUS

1962 • 113 citations

Determination of urinary 3-methoxy-4-hydroxyphenyl-ethylene glycol by gas-liquid chromatography and electron capture detection

1967 • 108 citations

L-Dihydroxyphenylalanine: Effect on S -Adenosylmethionine in Brain

1970 • 104 citations

Effect of Probenecid on the Levels of Monoamine Metabolites in the Rat Brain

1967 • 102 citations

Catecholamines and mania: The effect of alpha‐methyl‐para‐tyrosine on manic behavior and catecholamine metabolism

1971 • 99 citations

Effects of L-Dopa on Norepinephrine Metabolism in the Brain

1971 • 97 citations

Evaluation of the biochemical effects produced in vivo by inhibitors of the three enzymes involved in norepinephrine biosynthesis.

1966 • 89 citations

The quantitative determination of 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid) in urine.

1965 • 87 citations

Mental Effects of High-Dosage Levodopa

1971 • 84 citations

Playing the Manic Game

1970 • 80 citations

Clinical experience with dihydroxyphenylalanine (DOPA) in depression

1963 • 79 citations

ADMINISTRATION OF A PERIPHERAL DECARBOXYLASE INHIBITOR WITH L-DOPA TO DEPRESSED PATIENTS

1970 • 78 citations

EFFECT OF L-DOPA ON DEPRESSION

1969 • 65 citations

The Estimation of Total (Free + Conjugated) Catecholamines and Some Catecholamine Metabolites in Human Urine

1968 • 56 citations

Effect of L-DOPA treatment on brain serotonin metabolism in depressed patients

1971 • 54 citations

A study of bipolar and unipolar recurrent depressive psychosis

1966 • 52 citations

Effect of probenecid on the level of homovanillic acid in the corpus striatum

1966 • 48 citations

L-dopa-induced accumulation of 3-O-methyldopa in brain and heart

1970 • 45 citations

Determination of catecholamines and catecholamino acids by differential spectrophotofluorimetry.

1961 • 37 citations

CSF 5HIAA: Effects of probenecid and parachlorophenylalanine

1968 • 35 citations

METHYSERGIDE IN MANIA

1969 • 34 citations

L-DOPA IN DEPRESSED PATIENTS

1970 • 31 citations

Die Wirkung von Dopa auf gehemmte Depressionen

1966 • 29 citations

Mechanism of Norepinephrine Depletion by 5-Hydroxytryptophan

1968 • 25 citations

A CLINICAL TRIAL OF PARGYLINE AND DOPA IN PSYCHOTIC SUBJECTS.

1964 • 23 citations

Strychnine Antagonism and Glycine: a Reply

1970 • 19 citations

Deaths From Aspiration and Asphyxiation in a Mental Hospital

1968 • 12 citations