Genetic Variability and Antigenic Diversity of Foot-and-Mouth Disease Virus

Atlas of protein sequence and structure

1965 • 4,462 citations

Selforganization of matter and the evolution of biological macromolecules

1971 • 3,737 citations

Rapid Evolution of RNA Genomes

1982 • 1,475 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

The Hypercycle

1979 • 887 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

1989 • 854 citations

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

1982 • 826 citations

Rates of DNA Sequence Evolution Differ Between Taxonomic Groups

1986 • 793 citations

Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

1989 • 655 citations

Rapid Evolution of RNA Viruses

1987 • 593 citations

Nucleotide sequence heterogeneity of an RNA phage population

1978 • 557 citations

The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance — a review

1985 • 523 citations

Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine

1981 • 504 citations

Myristylation of picornavirus capsid protein VP4 and its structural significance

1987 • 475 citations

Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide

1986 • 397 citations

The Cell Attachment Site on Foot-and-Mouth Disease Virus Includes the Amino Acid Sequence RGD (Arginine-Glycine-Aspartic Acid)

1989 • 389 citations

Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein

1982 • 365 citations

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

1982 • 364 citations

The Atomic Structure of Mengo Virus at 3.0 Å Resolution

1987 • 353 citations

Foot-And-Mouth Disease

1968 • 338 citations

Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein

1987 • 335 citations

Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex

1988 • 319 citations

The Interferon Genes

1986 • 304 citations

Nucleotide sequence and genome organization of foot-and-mouth disease virus

1984 • 295 citations

Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

1985 • 289 citations

Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination

1987 • 286 citations

Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture

1983 • 269 citations

The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate

1976 • 235 citations

Evolution of RNA Viruses

1988 • 235 citations

Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants

1987 • 216 citations

Immune and Antibody Responses to an Isolated Capsid Protein of Foot-and-Mouth Disease Virus

1975 • 214 citations

Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus

1980 • 203 citations

Potyviral proteins share amino acid sequence homology with picorna-, como-, and caulimoviral proteins

1987 • 194 citations

Chemical basis of antigenic variation in foot-and-mouth disease virus

1983 • 183 citations

Antigenic sites on foot-and-mouth disease virus type A10

1988 • 180 citations

Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle

1988 • 178 citations

Direct method for quantitation of extreme polymerase error frequencies at selected single base sites in viral RNA

1986 • 173 citations

Biochemical identification of viruses causing the 1981 outbreaks of foot and mouth disease in the UK

1981 • 171 citations

Neutralization of Foot-and-Mouth Disease Virus Can Be Mediated Through Any of at least Three Separate Antigenic Sites

1987 • 169 citations

Analysis of neutralizing antigenic sites on the surface of type A12 foot-and-mouth disease virus

1989 • 163 citations

The duration of the foot-and-mouth disease virus carrier state in African buffalo (i) in the individual animal and (ii) in a free-living herd

1985 • 162 citations

Evolution of multiple genome mutations during long-term persistent infection by vesicular stomatitis virus

1979 • 157 citations

Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12

1985 • 153 citations

The Mutation Rate and Variability of Eukaryotic Viruses: An Analytical Review

1987 • 151 citations

Studies on the carrier state of cattle exposed to foot-and-mouth disease virus

1966 • 149 citations

Recombination in RNA

1982 • 143 citations

Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture

1988 • 142 citations

Novel low-molecular-weight synthetic vaccine against foot-and-mouth disease containing a potent B-cell and macrophage activator

1989 • 140 citations

The complete nucleotide sequence of the RNA coding for the primary translation product of foot and mouth disease virus

1984 • 139 citations

In vitro site-directed mutagenesis: Generation and properties of an infectious extracistronic mutant of bacteriophage Qβ

1976 • 130 citations

Cloning of cDNA of major antigen of foot and mouth disease virus and expression in E. coli

1981 • 128 citations

The pathogenesis of natural and simulated natural foot-and-mouth disease infection in cattle

1981 • 126 citations

Establishment of cell lines persistently infected with foot-and-mouth disease virus

1985 • 126 citations

Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.

1989 • 124 citations

Infection of cattle by airborne foot-and-mouth disease virus: minimal doses with O1 and sat 2 strains

1987 • 122 citations

Vesicular stomatitis virus defective interfering particles can contain extensive genomic sequence rearrangements and base substitutions

1984 • 120 citations

Surface Structure of Foot-and-Mouth Disease Virus

1969 • 117 citations

Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease

1987 • 116 citations

High frequency of antigenic variants among naturally occurring human Coxsackie B4 virus isolates identified by monoclonal antibodies

1982 • 114 citations

The epizootiological importance of foot-and-mouth disease carriers

1968 • 110 citations

Characterization of a seal morbillivirus

1988 • 110 citations

Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations

1986 • 109 citations

Antigenic variation in foot-and-mouth disease: studies based on the virus neutralization reaction

1984 • 109 citations

Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts

1987 • 108 citations

Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C

1988 • 103 citations

Immune response to uncoupled peptides of foot-and-mouth disease virus.

1987 • 101 citations

A tandem repeat gene in a picornavirus

1982 • 101 citations

Extreme heterogeneity in populations of vesicular stomatitis virus

1989 • 100 citations

Structure of the FMDV translation initiation site and of the structural proteins

1983 • 99 citations

Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus

1987 • 98 citations

Epitope Mapping of Foot-and-Mouth Disease Virus with Neutralizing Monoclonal Antibodies

1989 • 98 citations

Epitopes on foot-and-mouth disease virus outer capsid protein VP1 involved in neutralization and cell attachment

1984 • 97 citations

Evidence for At Least Four Antigenic Sites on Type O Foot-and-Mouth Disease Virus Involved in Neutralization; Identification by Single and Multiple Site Monoclonal Antibody-resistant Mutants

1989 • 96 citations

Neutralizing Epitopes of Type O Foot-and-Mouth Disease Virus. II. Mapping Three Conformational Sites with Synthetic Peptide Reagents

1989 • 92 citations

Properties of different artificial antigens immunologically related to tobacco mosaic virus

1965 • 92 citations

Host Cell Selection of Antigenic Variants of Foot-and-Mouth Disease Virus

1989 • 91 citations

Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus

1981 • 91 citations

Fusion Proteins with Multiple Copies of the Major Antigenic Determinant of Foot-and-Mouth Disease Virus Protect both the Natural Host and Laboratory Animals

1987 • 90 citations

Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus

1982 • 88 citations

Continuing coevolution of virus and defective interfering particles and of viral genome sequences during undiluted passages: virus mutants exhibiting nearly complete resistance to formerly dominant defective interfering particles

1987 • 87 citations

Comparison of the Antibodies Elicited by the Individual Structural Polypeptides of Foot-and-Mouth Disease and Polio Viruses

1979 • 87 citations

Immune protection against foot-and-mouth disease virus studied using virus-neutralizing and non-neutralizing concentrations of monoclonal antibodies.

1986 • 87 citations

Transmission of foot-and-mouth disease from African buffalo virus carriers to bovines

1985 • 85 citations

Rapid correlation between field isolates and vaccine strains of foot-and-mouth disease virus

1988 • 84 citations

Development of foot-and-mouth disease virus strain characterisation—A review

1989 • 82 citations

Neutralizing Epitopes of Type O Foot-and-Mouth Disease Virus. I. Identification and Characterization of Three Functionally Independent, Conformational Sites

1989 • 82 citations

High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus

1989 • 80 citations

Poly(C) in animal viral RNAs

1974 • 79 citations

Exposure of sheep to natural aerosols of foot-and-mouth disease virus

1986 • 78 citations

T Cell-dependent Induction of Antibody against Foot-and-Mouth Disease Virus in a Mouse Model

1989 • 76 citations

New Concepts for Dealing with the Evolution of Nucleic Acids

1987 • 75 citations

Multiple sites of recombination within the RNA genome of foot-and-mouth disease virus

1985 • 73 citations

Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus

1988 • 72 citations

The Virus of Foot-and-Mouth Disease

1958 • 72 citations

Comparison of the major antigenic determinants of different serotypes of foot-and-mouth disease virus

1983 • 71 citations

Gene encoding capsid protein VP1 of foot-and-mouth disease virus: a quasispecies model of molecular evolution.

1988 • 69 citations

Location of the initiation site for protein synthesis on foot-and-mouth disease virus RNA by in vitro translation of defined fragments of the RNA

1980 • 68 citations

The nucleotide sequence of cDNA coding for the structural proteins of foot-and-mouth disease virus

1982 • 68 citations

Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

1985 • 66 citations

Neutralization sites of type 01 foot-and-mouth disease virus defined by monoclonal antibodies and neutralization-escape virus variants

1988 • 64 citations

Processing and Assembly of Foot-and-Mouth Disease Virus Proteins Using Subgenomic RNA

1988 • 64 citations

Role of epidemiology in vaccine policy

1990 • 64 citations

The molecular basis of the antigenic variation of foot-and-mouth disease virus.

1983 • 63 citations

Ribavirin cures cells of a persistent infection with foot-and-mouth disease virus in vitro

1987 • 61 citations

Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus

1987 • 60 citations

Epitopes on foot-and-mouth disease virus particles I. Topology

1987 • 60 citations

More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA

1978 • 59 citations

3′-Terminal nucleotide sequences in the genome RNA of picornaviruses

1978 • 58 citations

Immune response to foot-and-mouth disease virus in a murine experimental model: effective thymus-independent primary and secondary reaction.

1986 • 58 citations

Guanidine-dependent mutants of poliovirus: Identification of three classes with different growth requirements

1987 • 58 citations

Extensive cell heterogeneity during persistent infection with foot-and-mouth disease virus

1989 • 56 citations

High multiplicities of infection favor rapid and random evolution of vesicular stomatitis virus

1982 • 56 citations

Selection of Antigenic Variants of Foot-and-Mouth Disease Virus in the Absence of Antibodies, as Revealed by an in situ Assay

1989 • 55 citations

Heterogeneity of the polyribocytidylic acid tract in aphthovirus: biochemical and biological studies of viruses carrying polyribocytidylic acid tracts of different lengths

1984 • 54 citations

Molecular cloning of foot and mouth disease virus genome and nucleotide sequences in the structural protein genes

1981 • 53 citations

Analysis of Foot-and-Mouth Disease Virus Type O1 Brugge Neutralization Epitopes Using Monoclonal Antibodies

1986 • 52 citations

Detection of conserved and nonconserved epitopes on coxsackievirus B4: Frequency of antigenic change

1985 • 51 citations

Recombination and oligonucleotide analysis of guanidine-resistant foot-and-mouth disease virus mutants

1985 • 49 citations

Isolation and biochemical characterization of intertypic recombinants of foot-and-mouth disease virus

1985 • 48 citations

VP1 of serotype C foot-and-mouth disease viruses: long-term conservation of sequences

1988 • 47 citations

An Assessment by Competition Hybridization of the Sequence Homology between the RNAs of the Seven Serotypes of FMDV

1977 • 47 citations

Foot-and-Mouth Disease Virus Immunogenic Capsid Protein VP<sub>T</sub>: N-Terminal Sequences and Immunogenic Peptides Obtained by CNBr and Tryptic Cleavages

1979 • 47 citations

Location of neutralizing epitopes defined by monoclonal antibodies generated against the outer capsid polypeptide, VP1, of foot-and-mouth disease virus A12

1984 • 47 citations

Molecular cloning of cDNA from foot-and-mouth disease virus C1-Santa Pau (C-S8). Sequence of protein-VP1-coding segment

1983 • 44 citations

Bacterially expressed antigenic peptide from foot-and-mouth disease virus capsid elicits variable immunologic responses in animals.

1986 • 43 citations

Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis

1990 • 43 citations

Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8)

1985 • 43 citations

The sequence of foot-and-mouth disease virus RNA to the 5′ side of the poly(C) tract

1985 • 43 citations

What does the molecular structure of viruses tell us about viral functions?

1987 • 40 citations

Inhibition of cell-free foot-and-mouth disease virus-ribonucleic acid synthesis by antibody

1967 • 40 citations

The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP1

1983 • 39 citations

Comparative Biochemical and Serological Analysis of Five Isolates of a Single Serotype of Foot-and-Mouth Disease Virus

1979 • 39 citations

Crossover regions in foot-and-mouth disease virus (FMDV) recombinants correspond to regions of high local secondary structure

1988 • 38 citations

Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus

1976 • 37 citations

Vesicular stomatitis virus mutants resistant to defective-interfering particles accumulate stable 5'-terminal and fewer 3'-terminal mutations in a stepwise manner

1984 • 37 citations

Prediction of three-dimensional models for foot-and-mouth disease virus and hepatitis a virus

1988 • 37 citations

Use of peptides for immunization againast foot-and-mouth disease

1988 • 36 citations

Epitope mapping of the outer structural protein VP1 of three different serotypes of foot-and-mouth disease virus

1986 • 35 citations

Morphogenesis of vesiculation in foot-and-mouth disease.

1980 • 31 citations

Immunization against Foot-and-Mouth Disease with Synthetic Peptides Representing the C-terminal Region of VP1

1988 • 31 citations

The structural polypeptides of aphthovirus are phosphoproteins.

1980 • 30 citations

Synthesis of fusion proteins with multiple copies of an antigenic determinant of foot-and-mouth disease virus antibodies

1986 • 30 citations

Evolution of enterovirus type 70: Oligonucleotide mapping analysis of RNA genome

1984 • 30 citations

Antigenic variation of foot-and-mouth disease virus of serotype C during propagation in the field is mainly restricted to only one structural protein (VP1)

1989 • 28 citations

Studies on the Infectivity of Foot-and-Mouth Disease Virus RNA using Microinjection

1988 • 28 citations

Isolation of a foot-and-mouth disease polyuridylic acid polymerase and its inhibition by antibody

1980 • 27 citations

An Epitope Located at the C Terminus of Isolated VP1 of Foot-and-Mouth Disease Virus Type O Induces Neutralizing Activity but Poor Protection

1986 • 27 citations

Resistance to foot-and-mouth disease virus mediated by trans-acting cellular products

1989 • 26 citations

3D gene of foot-and-mouth disease virus

1988 • 26 citations

Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus

1984 • 26 citations

Heterogeneity of the polyribocytidilic acid tract in aphthovirus: changes in the size of the poly(C) of viruses recovered from persistently infected cattle

1988 • 25 citations

Crystallization and preliminary X-ray diffraction analysis of foot-and-mouth disease virus

1987 • 25 citations

Antigenic comparison of foot-and-mouth disease virus serotypes with monoclonal antibodies

1986 • 24 citations

Role of Langerhans cells in the infection of the guinea-pig epidermis with foot-and-mouth disease virus

1985 • 24 citations

Sequences of capsid protein VP1 of two type a foot-and-mouth disease viruses

1989 • 23 citations

Finding the receptors

1989 • 22 citations

Polynucleotide Sequence Homologies among the RNAs of Foot-and-Mouth Disease Virus Types A, C and O

1971 • 22 citations

Modification of the Leader Protein (Lb) of Foot-and-Mouth Disease Virus

1988 • 21 citations

Synthetic peptides mimic subtype specificity of foot‐and‐mouth disease virus

1983 • 19 citations

Analysis of the Secondary Structure of the Poly(C) Tract in Foot-and-Mouth Disease Virus RNAs

1985 • 18 citations

Neutralization Epitope Diversity of Coxsackievirus B4 Isolates Detected by Monoclonal Antibodies

1986 • 18 citations

Synthetic peptides as the basis for future vaccines

1982 • 17 citations

Microscopic skin lesions in cattle with foot-and-mouth disease

1968 • 16 citations

Isolation of a variant strain of foot-and-mouth disease virus (type O) during passage in partly immunized cattle

1966 • 16 citations

THE VIRUS OF FOOT‐AND‐MOUTH DISEASE

1962 • 15 citations

Localization of a Neutralization Epitope of Foot-and-Mouth Disease Virus Using Neutralizing Monoclonal Antibodies

1984 • 15 citations

Characterization of Anti-idiotypic Antibodies Generated Against Foot-and-Mouth Disease Virus Neutralizing Monoclonal Antibodies

1989 • 15 citations

Persistent foot-and-mouth disease infections of cells in tissue culture

1959 • 14 citations

Heterogeneity of human immunodeficiency virus cell-associated antigens and demonstration of virus type specificities of human antibody responses

1987 • 14 citations

A possible role of capybaras (Hydrochoerus hydrochoeris hydrochoeris) in foot-and-mouth disease (FMD) endemicity

1984 • 14 citations

Point mutations in polypeptide VP1 of foot-and-mouth disease virus affect mouse virulence and BHK21 cell pathogenicity

1983 • 10 citations

Structure-Function Relationships in the Picornaviruses

1979 • 10 citations

The nucleotide sequence of the structural-protein-coding region of foot-and-mouth disease virus serotype SAT3

1989 • 10 citations

Biotechnological Approach to a new Foot-and-Mouth Disease Virus Vaccine

1984 • 8 citations

Nucleotide sequence of the VP1 gene of the foot-and-mouth disease virus strain A Venceslau

1984 • 7 citations

Isolation of immunizing cyanogen bromide-peptides of foot-and-mouth disease virus

1978 • 6 citations

The carrier state in cattle in foot-and-mouth disease

1969 • 4 citations

The susceptibility of three British small mammals to foot-and-mouth disease

1971 • 4 citations

Genetic engineering and foot and mouth disease vaccines

1981 • 4 citations

Note on the Spectrum of Didymium 1

1887 • 3 citations

Foot-and-mouth disease--a world problem.

1979 • 2 citations