Strategies for Developing Specific and Sensitive Hapten Radioimmunoassays

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent

1978 • 1,226 citations

Common precursor to corticotropins and endorphins

1977 • 1,106 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

STEROID-PROTEIN CONJUGATES

1957 • 798 citations

Principles of Competitive Protein-Binding Assays.

1972 • 522 citations

The Specificity of Serological Reactions

1945 • 484 citations

Steroid-Protein Conjugates

1959 • 357 citations

Radioimmunoassay and characterization of enkephalins in rat tissues.

1978 • 288 citations

The Preparation of Peptides Using Mixed Carbonic—Carboxylic Acid Anhydrides

1952 • 285 citations

RADIOIMMUNOASSAY OF STEROIDS

1970 • 273 citations

RADIOIMMUNOASSAY OF STEROIDS IN BIOLOGICAL MATERIALS

1974 • 263 citations

Adenosine 3′,5′ cyclic monophosphate assay at 10−15 mole level

1973 • 262 citations

Guanosine 3' ,5'-Cyclic Monophosphate Assay at 10−15-Mole Level

1976 • 256 citations

Digoxin-specific antibodies.

1967 • 252 citations

The Preparation and Specificity of Antibody to Thyrotropin Releasing Hormone1

1972 • 245 citations

Oxytocin in Human Plasma: Correlation with Neurophysin and Stimulation with Estrogen*

1981 • 173 citations

Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist

1980 • 151 citations

RADIOIMMUNOASSAY OF METHIONINE‐AND LEUCINE‐ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY

1978 • 149 citations

Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies.

1982 • 129 citations

Principles and methods for the preparation of drug protein conjugates for immunological studies.

1973 • 125 citations

Covalent attachment of proteins to polysaccharide carriers by means of benzoquinone

1975 • 122 citations

Identification of the octapeptide [Met]enkephalin -Arg6-Gly7-Leu8 in extracts of bovine adrenal medulla

1981 • 118 citations

Antibodies to Indolealkylamines; Serotonin and Melatonin

1974 • 113 citations

Further Studies on the Radioimmunoassay of Gonadotropin-Releasing Hormone: Effect of Radioiodination, Antiserum and Unextracted Serum on Levels of Immunoreactivity in Serum¹

1977 • 111 citations

Quantitation of conformational changes on chemical modification of proteins: Use of succinylated proteins as a model

1967 • 105 citations

Antigenic complexes of steroid hormones formed by coupling to protein through position 7: Preparation from Δ4 -3-oxosteroids and characterization of antibodies to testosterone and androstenedione

1972 • 102 citations

Coupling of peptides to albumin with difluorodinitrobenzene.

1976 • 93 citations

Enkephalin: Radioimmunoassay and radioreceptor assay in morphine dependent rats

1977 • 88 citations

Improved 125I radioimmunoassay for cotinine by selective removal of bridge antibodies.

1985 • 87 citations

Some observations on the determination of testosterone in human plasma by radioimmunoassay using antisera raised against testosterone-3-BSA and testosterone-11α-BSA

1973 • 87 citations

Synthesis of Antigenic Branch-Chain Copolymers of Angiotensin and Poly-L-lysine^*

1965 • 86 citations

A strategy for radioimmunoassay of plasma progesterone with use of a homologous-site 125I-labeled radioligand.

1981 • 74 citations

Immunological methods in steroid determination

1972 • 72 citations

Pharmacokinetics of Gonadotropin-Releasing Hormone: Comparison of Subcutaneous and Intravenous Routes*

1984 • 68 citations

PLASMA-ARGININE-VASOPRESSIN RESPONSE TO INSULIN-INDUCED HYPOGLYCÆMIA

1977 • 64 citations

Production of Antibody against Bradykinin: Demonstration of Specificity by Complement Fixation and Radio-Immunoassay

1966 • 54 citations

Hapten-Radioimmunoassay for Steroid Hormones

1970 • 52 citations

Comparison between rat and rabbit anticyclic AMP antibodies—Specificity toward acyl derivatives of cyclic AMP

1973 • 48 citations

Principles of Competitive Protein-Binding Assays

1983 • 47 citations

Conjugation of p-Benzoquinone treated enzymes with antibodies and Fab fragments

1977 • 40 citations

Radioimmunoassay of lysergic acid diethylamide (LSD) in serum and urine by using antisera of different specificities.

1977 • 38 citations

Chloramphenicol-Specific Antibody

1966 • 37 citations

Simple extraction method and radioimmunoassay for somatostatin in human plasma.

1981 • 36 citations

Relationships between immunogen structure and antisera specificity in the narcotic alkaloid series.

1981 • 36 citations

Mechanism of Inactivation of Vasopressin and Oxytocin by the Isolated Perfused Rat Kidney*

1973 • 34 citations

Steroid radioimmunoassay--effect of shortened incubation time on specificity.

1981 • 33 citations

[43] Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: A method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11β,16ξ-cyclo-PGE2

1982 • 33 citations

Simple extraction method and radioimmunoassay for somatostatin in human plasma.

1981 • 33 citations

Radioimmunoassay of progesterone in unextracted serum.

1980 • 31 citations

PREPARATION OF AN ESTRONE–PROTEIN CONJUGATE

1958 • 29 citations

Prevention of bridge binding effects in haptenic immunoassay systems exemplified by an iodinated radioimmunoassay for melatonin

1984 • 29 citations

A new improvement of the sensitivity and specificity of radioimmunoassay for thyroliberin. Application to biological samples

1982 • 28 citations

Lack of specificity of current anti-digoxin antibodies, and preparation of a new, specific polyclonal antibody that recognizes the carbohydrate moiety of digoxin.

1985 • 28 citations

Radioimmunoassay of [d-Trp6]-luteinizing hormone-releasing hormone: its application to animal pharmacokinetic studies after single injection and long-acting formulation administration

1986 • 23 citations

I — preparation of steroid-antigens through positions of the steroid not bearing functional groups

1974 • 23 citations

Development of a simple procedure for the preparation of semipermeable antibody-containing microcapsules and their analytical performance in a radioimmunoassay for 17-hydroxyprogesterone

1984 • 23 citations

Antiserum to 5α-dihydrotestosterone: Production, characterization and use in radioimmunoassay

1974 • 22 citations

Monoclonal antibodies against Met-enkephalin as probe in the central nervous system

1983 • 21 citations

[38] Problems of PGE antisera specificity

1982 • 19 citations

[42] Iodinated derivatives as tracers for eicosanoid radioimmunoassays

1982 • 18 citations

Characterization of monoclonal antibodies against prostaglandin E2: Fine specificity and neutralization of biological effects

1985 • 16 citations

Assay design and quality control

1979 • 16 citations

Immobilization of ligands for affinity chromatography. A comparative study of two condensation agents: 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide-metho-p-toluene sulfonate (CMC) and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)

1978 • 16 citations

Advantage of Florisil over charcoal separation in a mechanized testosterone radioimmunoassay.

1980 • 16 citations

A novel immunization procedure for production of anti-testosterone and anti-5α-dihydrotestosterone antisera of low cross-reactivity

1980 • 15 citations

Microencapsulated antibodies in radioimmunoassay. II. Determination of free thyroxine.

1979 • 13 citations

Preparation of dehydroepiandrosterone, testosterone and progesterone antigens through 7-carboxymethyl derivatives: Characteristics of the antisera to testosterone and progesterone

1980 • 12 citations

Preparation of an ecdysone immunogen for radioimmunoassay work.

1980 • 8 citations

Microencapsulated antibodies in radioimmunoassay--I. Determination of digoxin.

1979 • 8 citations

Advantage of Florisil over charcoal separation in a mechanized testosterone radioimmunoassay.

1980 • 7 citations

Immobilization of ligands for affinity chromatography

1984 • 6 citations

Improvement of specificity of anti-testosterone and anti-5α-dihydrotestosterone rabbit antibodies by immunotolerance techniques

1984 • 6 citations

Microencapsulated antibodies in radioimmunoassay. III. Determination of cortisol.

1980 • 5 citations

Microencapsulated antibodies in radioimmunoassay. III. Determination of cortisol.

1980 • 5 citations

Viroimmunoenzymoassay for detection of anti-penicilloyl antibodies and penicilloyl residues: comparison of results obtained by radio-, viro- and enzymoimmunoassay.

1979 • 5 citations

Structural immunochemistry of melatonin-BSA binding, model of amino and indole groups cross-linking.

1980 • 4 citations

Specific antisera to androstanediols: Influence of the type of bridge and position of coupling

1978 • 3 citations

Synthesis of 7α- and β-carboxymethyl derivatives of cortisol, corticosterone, deoxycorticosterone and cortisone. Immunogenic properties of cortisol, corticosterone and deoxycorticosterone derivatives

1985 • 3 citations

[Determination of digoxin].

1971 • 1 citations

Deleted Work

1955 • 0 citations