Use of high-performance liquid chromatographic–mass spectrometric (LC–MS) techniques for the determination of nicotine and its metabolites

Practical HPLC Method Development

1997 • 1,697 citations

Practical HPLC Method Development

1993 • 1,530 citations

HPLC Columns, Theory, Technology, and Practice

1998 • 603 citations

Monodisperse aerosol generation interface for combining liquid chromatography with mass spectroscopy

1984 • 349 citations

Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry

1997 • 330 citations

Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: Absence of an isotope effect in the clearance of (S)-nicotine-3′,3′-d2 in humans

1991 • 236 citations

Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers

1993 • 235 citations

CAPILLARY ELECTROPHORESIS

1989 • 218 citations

Recent Advances in Bonded Phases for Liquid Chromatography

1987 • 198 citations

Atmospheric Pressure Ionization Mass Spectrometry

1981 • 161 citations

FROM IONS IN SOLUTION TO IONS IN THE GAS PHASE

1993 • 148 citations

[9] Continuous-flow fast atom bombardment mass spectrometry

1990 • 137 citations

Stable isotope studies of nicotine kinetics and bioavailability

1991 • 135 citations

Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3'-hydroxycotinine in smokers.

1992 • 128 citations

Smoking-induced changes in nicotine disposition: Application of a new HPLC assay for nicotine and its metabolites

1982 • 127 citations

Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system

1983 • 122 citations

Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking

1997 • 117 citations

Quantitation of major tobacco alkaloids by high-performance liquid chromatography

1981 • 104 citations

Investigation of enhanced ion abundances from a carrier process in high-performance liquid chromatography particle beam mass spectrometry

1990 • 96 citations

RECENT ADVANCES IN BONDED PHASES FOR LIQUID CHROMATOGRAPHY

1987 • 95 citations

Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.

1997 • 91 citations

A Novel Geometry Mass Spectrometer, the Q-TOF, for Low-Femtomole/Attomole-Range Biopolymer Sequencing

1997 • 91 citations

Liquid Chromatography/Mass Spectrometry

1990 • 81 citations

Rapid analysis of nicotine and cotinine in the urine of smokers by isocratic high-performance liquid chromatography

1977 • 71 citations

Practical HPLC Methodology and Applications

1993 • 70 citations

A further study of FTC yield and nicotine absorption in smokers

1998 • 69 citations

Evaluation of capillary electrophoresis for the analysis of nicotine and selected minor alkaloids from tobacco

1995 • 63 citations

CONTINUOUS-FLOW FAST ATOM BOMBARDMENT MASS SPECTROMETRY

1990 • 57 citations

Rapid method for the analysis of tobacco nicotine alkaloids

1981 • 56 citations

Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine

1992 • 55 citations

A New Quantitative Thermospray LC-MS Method for Nicotine and Its Metabolites in Biological Fluids

1990 • 55 citations

Simultaneous determination of nicotine, cotinine and five additional nicotine metabolites in the urine of smokers using pre-column derivatisation and high-performance liquid chromatography

1987 • 52 citations

Nicotine and related alkaloids : absorption, distribution, metabolism, and excretion

1993 • 51 citations

26th Annual Conference on Mass Spectrometry and Allied Topics

1978 • 50 citations

S(‐)‐Nornicotine Increases Dopamine Release in a Calcium‐Dependent Manner from Superfused Rat Striatal Slices

1993 • 48 citations

Is particle beam an up-to-date LC-MS interface? State of the art and perspectives

1996 • 47 citations

Species Variation and Stereoselectivity in the Metabolism of Nicotine Enantiomers

1988 • 45 citations

Radiometric-high-performance liquid chromatographic assay for nicotine and twelve of its metabolites

1987 • 42 citations

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine

1984 • 42 citations

Parotid and whole saliva in the prediction of serum total and free phenytoin concentrations

1978 • 37 citations

Evaluation of micellar electrokinetic capillar chromatography for the analysis of selected tobacco alkaloids

1996 • 34 citations

Chromatographic analysis of alkaloids

1991 • 34 citations

Assessment of exposure to environmental tobacco smoke using a high-performance liquid chromatographic method for the simultaneous determination of nicotine and two of its metabolites in urine

1988 • 33 citations

Metabolism of S-nicotine in noninduced and aroclor-induced rats

1993 • 31 citations

Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry

1994 • 30 citations

Application of high‐performance capillary electrophoresis to the quantitative analysis of nicotine and profiling of other alkaloids in ATF‐regulated tobacco products

1998 • 29 citations

Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.

1995 • 28 citations

A Novel Method for the Isolation and Quantitative Analysis of Nicotine and Cotinine in Biological Fluids*

1978 • 28 citations

Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase

1985 • 27 citations

Assessment of the automated colorimetric and the high-performance liquid chromatographic methods for nicotine intake by urine samples of smokers' smoking low- and medium-yield cigarettes

1991 • 27 citations

High-performance liquid chromatography with electrochemical detection for the determination of nicotine and N-methylnicotinium ion

1985 • 24 citations

Nicotine and metabolites: analysis and levels in body fluids

1993 • 23 citations

Enantioselective Metabolism During Continuous Administration of S-(−)- and R-(+)-Nicotine Isomers to Guinea-Pigs

1988 • 23 citations

[5] Liquid chromatography-mass spectrometry

1990 • 22 citations

Modified acetonitrile protein-precipitation method of sample preparation for drug assay by liquid chromatography.

1980 • 18 citations

Capillary electrophoresis as an analytical tool for monitoring nicotine in ATF regulated tobacco products

1997 • 18 citations

Orthogonal acceleration single-pass time-of-flight mass spectrometry for determination of the exact masses of product ions formed in tandem mass spectrometry experiments

1997 • 18 citations

Automation of a high-performance liquid chromatographic assay for the determination of nicotine, cotinine and 3-hydroxycotinine in human urine

1990 • 15 citations

Biotransformation of primary nicotine metabolites II. Metabolism of [³H]-S-(-)-cotinine in the guinea pig: determination ofin vivourinary metabolites by high-performance liquid-radiochromatography

1987 • 15 citations

Pharmacokinetics of (S)-nicotine and metabolites in humans

1993 • 14 citations

Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig.

1984 • 12 citations

Isolation and characterization of N-methyl-N'-oxonicotinium ion, a new urinary metabolite of R-(+)-nicotine in the guinea pig.

1986 • 12 citations

High-Performance Liquid Chromatography with Electrochemical Detection for the Determination of Nicotine in Plasma

1988 • 11 citations

N-Methylnornicotinium ion, a new in vivo metabolite of R-(+)-nicotine.

1985 • 11 citations

N-Oxidation, N-methylation and N-conjugation reactions of nicotine

1993 • 11 citations

Simultaneous Determination of Diphenhydramine, Methaqualone, Diazepam and Chlorpromazine in Liver by Use of Enzyme Digestion: A Comparison of Digestion Procedures

1981 • 8 citations

Biotransformation of Primary Nicotine Metabolites: Metabolism of R-(+)-[3H-N′-CH3; 14C-N-CH3] N-Methylnicotinium Acetate—The Use of Double Isotope Studies to Determine the In-vivo Stability of the N-Methyl Groups of N-Methylnicotinium Ion

1988 • 4 citations