Recent Developments of the Blood-Brain Barrier Concept

Handbook of Physiology.

1960 • 10,428 citations

Passage of Molecules Through Capillary Walls

1953 • 942 citations

Morphological classifications of vertebrate blood capillaries

1959 • 628 citations

Structure and function of the cerebral cortex

2007 • 592 citations

Injections of drugs into the lateral ventricle of the cat

1954 • 514 citations

THE FINE STRUCTURE OF CAPILLARIES AND SMALL ARTERIES

1957 • 427 citations

THE EFFECT OF CHANGES IN THE CALCIUM CONTENT OF THE CEREBROSPINAL FLUID ON SPINAL REFLEX ACTIVITY IN THE DOG

1940 • 363 citations

THE CEREBROSPINAL FLUID VALVES

1960 • 310 citations

Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood

1961 • 301 citations

Electron microscopy of muscular arteries; pial vessels of the cat and monkey

1960 • 293 citations

Electron microscopy of the vascular bed of rat cerebral cortex

1957 • 290 citations

Physiology of the Ocular and Cerebrospinal Fluids

1957 • 276 citations

Secretion of organic anions in the formation of urine and bile.

1959 • 262 citations

The Blood-Brain Barrier

1961 • 256 citations

The importance of dissociaton constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid.

1960 • 256 citations

Die Bedeutung der vitalen Färbung für die Lehre vom Stoffaustausch zwischen dem Zentralnervensystem und dem übrigen Körper

1934 • 251 citations

Function of astroglia in the water‐ion metabolism of the central nervous system

1959 • 231 citations

Exchange Diffusion, Transport, and Intracellular Level of Amino Acids in Ehrlich Carcinoma Cells

1958 • 217 citations

Biology and pharmacology of the lithium ion.

1957 • 216 citations

Active Sodium and Chloride Transport in the Single Celled Marine Alga Halicystis Ovalis

1960 • 209 citations

Die Feinstruktur des molekularen Rindengraues und ihre physiologische Bedeutung

1959 • 207 citations

Uptake of Tyrosine by Rat Brain in Vivo

1960 • 182 citations

The application of fluorescein labeled serum proteins (FLSP) to the study of vascular permeability in the brain

1962 • 180 citations

Transcapillary Exchange of Water and of Other Substances in Certain Organs of the Dog

1955 • 176 citations

Correlation of Brain Metabolism and Function by the Use of a Brain Perfusion Method In Situ

1958 • 168 citations

KINETICS OF PENETRATION OF DRUGS AND OTHER FOREIGN COMPOUNDS INTO CEREBROSPINAL FLUID AND BRAIN

1959 • 159 citations

The blood—brain barrier and the extracellular space of brain

1959 • 156 citations

Submicroscopic Morphology and Function of Glial Cells

1961 • 153 citations

Water Exchange of Central Nervous System and Cerebrospinal Fluid

1952 • 152 citations

Penetration of bromophenol blue from the perfused cerebral ventricles into the brain tissue

1960 • 151 citations

Autoradiographic Investigation of Incorporation of H ³ -Thymidine into Cells of the Rat and Mouse

1960 • 148 citations

Lithium Studies. 3. Distribution between Serum and Tissues.

1958 • 146 citations

The histochemical localization of acid and alkaline phosphatases, non‐specific esterase and succinic dehydrogenase in the structures comprising the hematoencephalic barrier of the rat

1952 • 133 citations

THE BRAIN BARRIER SYSTEM‐II UPTAKE AND TRANSPORT OF AMINO ACIDS BY THE BRAIN*

1961 • 129 citations

Slowly Changing Bioelectric Potentials Associated With the Blood-Brain Barrier

1958 • 128 citations

Perfusion of particles through arachnoid villi of the monkey

1961 • 124 citations

Quantitative studies of the passage of different substances out of the cerebro‐spinal fluid

1962 • 123 citations

The effect of diffusional barriers upon the pharmacology of cells within the central nervous system

1958 • 123 citations

The fine structure of cerebral fluid accumulation. II. Swelling produced by triethyl tin poisoning and its comparison with that in the human brain.

1960 • 121 citations

Protein Metabolism in the Nervous System

1961 • 119 citations

BLOOD-BRAIN BARRIER

1942 • 119 citations

The fine structure of cerebral fluid accumulation. I. Swelling secondary to cold injury.

1959 • 119 citations

Electron Micropscopy of the Brain in Experimental Edema

1960 • 118 citations

The Uptake of Tyrosine by Rat Brain in Vitro

1961 • 118 citations

Effect of Blood Constituents on Uptake of Glucose and on Metabolic Rate of the Brain in Perfusion Experiments

1954 • 117 citations

Effects of Alpha Particle Radiation on the Rat Brain, Including Vascular Permeability and Glycogen Studies

1961 • 114 citations

FLUID FORMED BY CHOROID PLEXUS: A TECHNIQUE FOR ITS COLLECTION AND A COMPARISON OF ITS ELECTROLYTE COMPOSITION WITH SERUM AND CISTERNAL FLUIDS

1960 • 113 citations

Renal tubular excretion of organic bases.

1960 • 113 citations

Physiology of the Ocular and Cerebrospinal Fluids

1957 • 110 citations

Electrolyte distribution in mammalian central nervous system: Are glia high sodium cells?

1961 • 109 citations

Observations on Pixocytosis in Nervous Tissue*

1960 • 108 citations

Chemosensitivity of the Respiratory Center

1953 • 108 citations

Biology of neuroglia

1958 • 106 citations

Pathways of absorption of protein from the cerebrospinal fluid: An autoradiographic study in the cat

1957 • 105 citations

THE BRAIN BARRIER SYSTEM–III

1962 • 101 citations

Increased cerebrovascular permeability after repeated electroshocks

1961 • 98 citations

Chloride movements in cerebral cortex after circulatory arrest and during spreading depression

1959 • 95 citations

Phenylalanine as Inhibitor of Transport of Amino-Acids in Brain

1961 • 90 citations

The Biology of Mental Health and Disease

1953 • 88 citations

THE ROLE OF pH GRADIENT IN THE DISTRIBUTION OF AMMONIA BETWEEN BLOOD AND CEREBROSPINAL FLUID, BRAIN AND MUSCLE*

1959 • 86 citations

Distribution of drugs between blood and cerebrospinal fluid: general methodology and effect of pH gradients.

1959 • 85 citations

Acid-base regulation by the kidneys

1950 • 83 citations

The influence of calcium, potassium and magnesium ions in cerebrospinal fluid on vasomotor system

1949 • 80 citations

PERIVASCULAR SPACES OF THE MAMMALIAN CENTRAL NERVOUS SYSTEM

1954 • 77 citations

ABNORMALITY OF THE BLOOD-CEREBROSPINAL FLUID BARRIER OF PATIENTS SUFFERING FROM A DEPRESSIVE ILLNESS

1960 • 74 citations

Mechanisms of renal tubular transport

1958 • 73 citations

The perivascular spaces of the mammalian central nervous system and their relation to the perineuronal and subarachnoid spaces.

1955 • 72 citations

The Transport of Organic Anions by the Rabbit Eye

1960 • 72 citations

Die Blut-Liquorschranke.

1934 • 72 citations

Experiments on the histologic locus of the hemato‐encephalic barrier

1955 • 70 citations

THE BRAIN BARRIER SYSTEM—I THE EXCHANGE OF FREE AMINO ACIDS BETWEEN PLASMA AND BRAIN

1961 • 70 citations

The Anatomy of the Cerebrospinal Fluid

1962 • 70 citations

Effect of ablation of medullary emetic chemoreceptor trigger zone on vomiting responses to cerebral intraventricular injection of adrenaline, apomorphine and pilocarpine in the cat

1959 • 69 citations

in vitro transport of dyes by isolated renal tubules of the flounder as disclosed by direct visualization. Intracellular accumulation and transcellular movement

1958 • 68 citations

The Transport of Organic Anions by the Rabbit Eye

1960 • 66 citations

The Anatomy of the Cerebro-Spinal Fluid

1963 • 65 citations

Penetration of radioactive bovine albumin from cerebrospinal fluid into brain tissue

1960 • 65 citations

FURTHER STUDIES ON SWELLING OF BRAIN SLICES

1962 • 65 citations

Absorption of histamine into the blood stream on perfusion of the cerebral ventricles, and its uptake by brain tissue

1960 • 63 citations

Sulfur-35 labeled acetazolamide in cat brain.

1959 • 62 citations

The effects of carbon dioxide on the entry and accumulation of drugs in the central nervous system.

1961 • 62 citations

The Blood-Brain Barrier With special regard to the use of radioactive isotopes

1957 • 62 citations

ON THE NATURE OF THE PIA MATER

1961 • 60 citations

Ultrastructure of Capillary Reaction to Brain Tumors

1961 • 60 citations

The Penetration of Carbon-14 Urea into Cerebrospinal Fluid and Various Areas of the Cat Brain

1960 • 58 citations

Body Fluid Indoles in Mental Illness

1961 • 57 citations

AN EXPLANATION OF THE BLOOD‐BRAIN BARRIER PHENOMENON

1958 • 57 citations

Phospholipid metabolism in nervous tissue. 2. Metabolic stability

1960 • 56 citations

FACTORS INFLUENCING THE EXCHANGE OF SODIUM BETWEEN PLASMA AND CEREBROSPINAL FLUID*†

1959 • 54 citations

Elektronenmikroskopische Untersuchungen �ber die Struktur der sogenannten Grundsubstanz in der Gro�- und Kleinhirnrinde des S�ugetieres

1959 • 54 citations

Ciba Foundation Symposium on the Cerebrospinal Fluid

1959 • 53 citations

[Electron microscopic studies on structural changes in the cerebral cortex in edema and their significance for the problem of ground substance].

1960 • 52 citations

Alkaline phosphomonoesterase and blood brain permeability.

1961 • 51 citations

Cerebrospinal fluid production and its relationship to cerebral metabolism and cerebral blood flow

1959 • 51 citations

THE INFLUENCE OF CARBON DIOXIDE INHALATION ON THE CEREBRAL VASCULAR PERMEABILITY TO TRYPAN BLUE (‘THE BLOOD‐BRAIN BARRIER’)

1958 • 49 citations

An improved technique for testing the effect of contrast media and other substances on the blood-brain Barrier

1958 • 48 citations

TRANSPORT MECHANISMS IN CERTAIN BLOOD‐BRAIN BARRIER PHENOMENA‐A HYPOTHESIS

1961 • 47 citations

Iodide transport by the rabbit eye

1961 • 45 citations

Reappraisal of the perivascular distribution of oligodendrocytes

1960 • 44 citations

Elektronenmikroskopische Untersuchungen �ber Strukturver�nderungen in der Hirnrinde beim �dem und ihre Bedeutung f�r das Problem der Grundsubstanz

1960 • 44 citations

Effect of temperature on function of isolated dog kidney

1959 • 43 citations

Biochemie des Aktiven Transports

1961 • 42 citations

Technique for the pharmaco-dynamic investigation of contrast media for cerebral angiography

1956 • 42 citations

The Uptake of Tyrosine by Isolated Rat Diaphragm

1960 • 42 citations

The Metabolic Activity of the Choroid Plexus

1959 • 42 citations

The Blood-Brain Barrier, with Special Regard to the Use of Radioactive Isotopes

1956 • 41 citations

Passage of lipid-insoluble substances from cerebrospinal fluid to blood.

1962 • 39 citations

The role of the meningeal tissues in the hemato‐encephalic barrier

1957 • 39 citations

Ueber Kollodiummembranen. III

1929 • 37 citations

Experimentelle elektronenmikroskopische Untersuchungen zum Ph�nomen der Membranvesikulation (Pinocytose)

1960 • 36 citations

Experimental study of the effects of hypothermia on local brain injury

1960 • 36 citations

Brain electrolytes and cortical impedance

1961 • 35 citations

The ultrastructure of normal and abnormal oligodendroglia

1960 • 35 citations

Studies on the Role of the Choroid Plexus in Tracer Exchanges between Blood and Cerebrospinal Fluid

1955 • 34 citations

THE BLOOD-BRAIN BARRIER PHENOMENON-THE RELATIVE IMPORTANCE OF PERMEABILITY AND CELLULAR TRANSPORT MECHANISMS

1961 • 34 citations

Studies in sodium exchange

1960 • 34 citations

The Clearance of Major Components of Whole Blood From Cerebrospinal Fluid Following Simulated Subarachnoid Hemorrhage

1961 • 33 citations

Urea in Intracranial Surgery

1961 • 32 citations

Localization of adenosinetriphosphatase in capillaries of the brain as revealed by electron microscopy

1961 • 31 citations

ON THE SOURCE OF THE CEREBROSPINAL FLUID. THE DISTRIBUTION OF BROMIDE AND IODIDE THROUGHOUT THE CENTRAL NERVOUS SYSTEM

1940 • 30 citations

Phospholipid metabolism in nervous tissue. 1. A reconsideration of brain and peripheral nerve phospholipid metabolism in vivo

1959 • 29 citations

Water Exchange in the Brain and Cerebrospinal Fluid

1954 • 28 citations

The distribution of oligodendrocytes in cerebral gray and white matter of several mammals

1960 • 27 citations

DISAPPEARANCE OF VARIOUS DRUGS FROM THE CEREBROSPINAL FLUID

1960 • 27 citations

Distribution of Carbon‐14 Labeled Isoniazid in Brain

1957 • 27 citations

Is the Perivascular Oligodendrocyte Another Element Controlling the Blood Supply to Neurons?

1960 • 25 citations

Transfer of Radioiodinated Human Serum Albumin (RISA(R)) from Cerebrospinal Fluid to Blood Plasma.

1960 • 23 citations

Phospholipid metabolism in nervous tissue. 3. The anatomical distribution of metabolically inert phospholipid in the central nervous system

1960 • 23 citations

The Prevention of Experimental Contrast Medium Injury to the Nervous System

1958 • 23 citations

An Autoradiographic Demonstration of the Relative Vascularity of the Central Nervous System of the Cat with Iodine 131-Labeled Serum Albumin

1958 • 22 citations

EFFECT OF HYPOTHERMIA UPON VITAL STAINING OF THE BRAIN1 A Study of the Blood-Brain Barrier

1960 • 21 citations

Filtration Coefficient of the Capillaries of the Brain

1958 • 20 citations

HISTOCHEMICAL IMPLICATIONS OF ELECTRON MICROSCOPY OF THE CENTRAL NERVOUS SYSTEM

1960 • 20 citations

Evaluation of Roentgen Contrast Agents Used in Cerebral Arteriography

1958 • 19 citations

Abolition by chlorpromazine of the inhibiting effect of iproniazid on the depletion of adrenal catechol amines induced by reserpine.

1959 • 19 citations

Evaluation of Roentgen Contrast Agents Used in Cerebral Arteriography

1958 • 19 citations

Changes in the Blood-Brain Barrier After Exposure of the Brain

1957 • 19 citations

In vitro and in vivo investigations of fowl erythroleukemia, with special reference to the virus-induced leukemic transformation of in vitro cultivated normal bone marrow cells.

1960 • 19 citations

Untersuchungen über die blut-liquor-passage bei psychosen

1926 • 19 citations

Passage of Saccharides from Cerebrospinal Fluid to Blood

1961 • 17 citations

Transport of ⁴²K from blood to cerebrospinal fluid in cats

1961 • 17 citations

Electron Microscopical Structure of the Wall of Small Blood Vessels in Human Multiform Glioblastoma

1959 • 17 citations

Localization of hematoencephalic barrier with fluorescent quaternary acridones.

1956 • 16 citations

Biology of Mental Health and Disease

1953 • 15 citations

Bemerkungen zu der Arbeit von <i>Hauptmann: </i>„Verminderte Durchlässigkeit der Blut-Liquorschranke bei Schizophrenie“.

1926 • 15 citations

Effect of urea on central nervous system activity in the cat

1959 • 15 citations

How Things get into Cells

1961 • 15 citations

�ber die Schrankenprobleme des Zentralnervensystems

1952 • 15 citations

The Cerebral Distribution and Migration of Radioisotopes with Special Reference to Autoradiograms*†

1959 • 14 citations

The Blood-Cerebrospinal Fluid Barrier in Man

1961 • 14 citations

Über die diagnostische Bedeutung der Walterschen Permeabilitätsreaktion

1929 • 13 citations

The Blood-Brain Barrier: An Expression of the Absence of Interstitial Spaces in Ectodermal Tissue?

1961 • 12 citations

Autoradiography of Carbon-14 Labeled Isoniazid in Brain.

1956 • 12 citations

Sodium and potassium activity of living brain. Relation to EEG and active sodium transport.

1961 • 11 citations

Zum Wirkungsmechanismus neuroplegischer Substanzen

1959 • 11 citations

Beeinflussung der Blut-Hirnschranke durch Neuroleptica im Dauerversuch

1961 • 11 citations

Further histochemical studies on the presence and nature of the ground substance of the central nervous system.

1958 • 10 citations

Perfusion of the ventricular system of the brain in the anaesthetized cat.

1957 • 10 citations

Relationship Between Cerebral Vascularity and P32 Uptake

1957 • 9 citations

Abnormal Blood‐brain Passage of a Quaternary Phenothiazine Derivative (S³⁵‐labelled Aprobit®) Induced by Chemical Agents

1962 • 8 citations

Properties of Membranes and Diseases of the Nervous System

1962 • 8 citations

THE FATE OF INTRACISTERNALLY INJECTED TRACER PHOSPHATE IN THE RABBIT, NORMALLY AND AS INFLUENCED BY SULPHYDRYL REAGENTS A KINETIC APPROACH TO THE MECHANISM OF THE BLOOD‐BRAIN BARRIER

1961 • 8 citations

Über Gefässpaare im Gehirn der Katze

1961 • 8 citations

Dispersion of Fluid Materials in Intracerebral Injections

1957 • 8 citations

CITRATE‐BUFFERED ⁵¹CrCl₃‐AN EXTRACELLULAR RADIO‐TRACER WITH POTENTIAL USE IN BLOOD‐BRAIN BARRIER STUDIES

1960 • 7 citations

BLOOD-CEREBROSPINAL FLUID BROMIDE RATIOS IN MENTAL PATIENTS

1959 • 6 citations

CITRATE‐BUFFERED ⁵¹CrCl₃—AN INDICATOR OF BLOOD‐BRAIN BARRIER DAMAGE—EXPERIMENTALLY COMPARED WITH IHSA

1961 • 6 citations

Effect of Urea on Enzyme Activity of the Choroid Plexus

1959 • 6 citations

PROPERTIES OF MEMBRANES AND DISEASES OF THE NERVOUS SYSTEM

1962 • 5 citations

A NOTE ON THE ANATOMY OF THE MENINGEAL BLOOD VESSELS. 3.

1960 • 4 citations

Über die Möglichkeit, den Stoffaustausch zwischen Blut und ZNS therapeutisch zu beeinflussen

1961 • 3 citations

�ber die antikonvulsive Wirkung der Nicotins�ure im Tierversuch

1961 • 1 citations