Interactions Between Chemokines and Other Cytokines in Host Response to Tumor

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Chemokines

1997 • 1,926 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

1996 • 1,196 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.

1993 • 523 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.

1995 • 459 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

1998 • 419 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.

1993 • 411 citations

Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.

1996 • 405 citations

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases.

1996 • 358 citations

Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.

1995 • 351 citations

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1994 • 335 citations

Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro.

1996 • 316 citations

The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer.

1995 • 314 citations

MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphoctye differentiation

1997 • 312 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

Interferon γ-Inducible Protein-10 (IP-10), a Member of the C-X-C Chemokine Family, Is an Inhibitor of Angiogenesis

1995 • 293 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.

1993 • 273 citations

Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.

1996 • 251 citations

Role of C-X-C chemokines as regulators of angiogenesis in lung cancer

1995 • 250 citations

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

1995 • 240 citations

β Chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production

1996 • 227 citations

Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.

1991 • 225 citations

Interferon-inducible protein-10 identified as a mediator of tumor necrosisin vivo

1996 • 223 citations

Specific adoptive immunotherapy mediated by tumor-draining lymph node cells sequentially activated with anti-CD3 and IL-2.

1991 • 217 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts.

1995 • 206 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens.

1995 • 191 citations

Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines.

1994 • 181 citations

Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

1995 • 172 citations

Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and interleukin-2.

1997 • 167 citations

Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12.

1996 • 166 citations

CC chemokines induce the generation of killer cells from CD56⁺ cells

1996 • 164 citations

Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells.

1996 • 149 citations

Human IP‐10 selectively promotes dominance of polyclonally activated and environmental antigen‐driven IFN‐γ over IL‐4 responses

1998 • 142 citations

RANTES Secretion by Gene-Modified Tumor Cells Results in Loss of TumorigenicityIn Vivo:Role of Immune Cell Subpopulations

1996 • 142 citations

Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

1993 • 142 citations

gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.

1995 • 138 citations

Chemokines: progress toward identifying molecular targets for therapeutic agents

1996 • 125 citations

Purification of L-Selectinlow Cells Promotes the Generation of Highly Potent CD4 Antitumor Effector T Lymphocytes

1998 • 110 citations

Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration

1995 • 106 citations

Chemoattractant stimulus-response coupling

1992 • 104 citations

Anti‐metastatic vaccination of tumor‐bearing mice with il‐2‐gene‐inserted tumor cells

1993 • 99 citations

Expression of theJE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells

1994 • 96 citations

Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines.

1994 • 95 citations

Antitumor activity of interleukin 12 in preclinical models

1996 • 94 citations

RANTES chemokine expression in diseased and normal human tissues

1996 • 89 citations

Interleukin-2-induced Tumor Necrosis Factor-alpha (TNF-α) Gene Expression in Human Alveolar Macrophages and Blood Monocytes

1989 • 85 citations

Inhibition of in vivo tumor growth by the beta chemokine, TCA3.

1994 • 83 citations

Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes.

1994 • 83 citations

Isolation based on L-selectin expression of immune effector T cells derived from tumor-draining lymph nodes.

1996 • 80 citations

A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors.

1995 • 71 citations

Monocyte chemoattractant protein-1 gene expression in prostatic hyperplasia and prostate adenocarcinoma.

1996 • 71 citations

Biological therapy of cancer

1986 • 65 citations

Chemokines and T lymphocyte activation: II. Facilitation of human T cell trafficking in severe combined immunodeficiency mice.

1996 • 60 citations

Immunotherapy of cancer with genetically modified tumor vaccines.

1996 • 59 citations

Treatment of intracranial tumors by systemic transfer of superantigen-activated tumor-draining lymph node T cells.

1996 • 58 citations

Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors

1995 • 58 citations

Cytokines in tumour growth, migration and metastasis

1996 • 47 citations

Current status of adoptive immunotherapy of cancer

1996 • 47 citations

Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model

1998 • 47 citations

The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice.

1996 • 41 citations

Suppression of Tumor Growth and Metastasis of Murine Renal Adenocarcinoma by Syngeneic Fibroblasts Genetically Engineered to Secrete the JE/MCP-1 Cytokine

1995 • 38 citations

Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages.

1993 • 38 citations

Interferon-inducible Protein 10 and Macrophage Inflammatory Protein-1α Inhibit Growth Factor Stimulation of Raf-1 Kinase Activity and Protein Synthesis in a Human Growth Factor-dependent Hematopoietic Cell Line

1995 • 36 citations

The Biological Therapy of Cancer

1992 • 36 citations

Differential regulation of lymphokine production by distinct subunits of the T cell interleukin 2 receptor.

1991 • 31 citations

Monocyte chemoattractant protein-1 stimulates tumor necrosis and recruitment of macrophages into tumors in tumor-bearing nude mice: increased granulocyte and macrophage progenitors in murine bone marrow.

1995 • 27 citations

Tumor angiogenesis: A physiological process or genetically determined?

1996 • 27 citations

The Chemokines: Cytokines that Direct Leukocyte Migration

1996 • 26 citations

Synergism between human recombinant monocyte chemotactic and activating factor and lipopolysaccharide for activation of antitumor properties in human blood monocytes.

1993 • 16 citations

Cellular and molecular studies in the treatment of murine renal cancer.

1995 • 15 citations

Gene therapy: its potential applications in the treatment of renal-cell carcinoma.

1995 • 12 citations

Adoptive immunotherapy mediated by anti-TCR/IL-2-activated tumour-draining lymph node cells.

1994 • 8 citations

Deleted Work

1955 • 0 citations